Hostname: page-component-76fb5796d-dfsvx Total loading time: 0 Render date: 2024-04-26T03:03:58.276Z Has data issue: false hasContentIssue false

Granular cell tumour of the larynx

Published online by Cambridge University Press:  29 June 2007

Ian A. Cree*
Affiliation:
Departments of Otolarynology and Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland.
Brian J. G. Bingham
Affiliation:
Departments of Otolarynology and Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland.
Keith C. R. B. Ramesar
Affiliation:
Departments of Otolarynology and Pathology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland.
*
Dr I. A. Cree, Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland

Abstract

A granular cell tumour may present as clinically innocuous lesions on the vocal cords and the diagnosis is usually made by histopathology. However, the granular cells characteristic of this tumour may not be obvious and accompanying epithelial hyperplasia may be interpreted by the pathologist as invasive squamous cell carcinoma. Good communication between pathologist and surgeon is required to ensure that clinically benign lesions on the vocal cords are not misdiagnosed. The diagnosis of granular cell tumour can be confirmed by immunocytochemical staining for S100 antigen.

Type
View from Beneath: Pathology in Focus
Copyright
Copyright © JLO (1984) Limited 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alessi, D. M. and Zimmerman, M. C. (1988) Granular cell tumors of the head and neck. Laryngoscope 98: 810814.CrossRefGoogle ScholarPubMed
Booth, J. B. and Osborn, D. A. (1970) Granular cell myoblastoma of the larynx. Acta Otolaryngologica 70: 279293.CrossRefGoogle ScholarPubMed
Buley, I. D., Gatter, K. C., Kelly, P. M. A., Heryet, A. and Millard, P. R. (1988) Granular cell tumours revisited. An immuno-histological and ultrastructural study. Histopathology 12: 263274.CrossRefGoogle Scholar
Campagno, J., Hyams, V. J. and Ste-Marie, P. (1975) Benign granular cell tumors of the larynx: a review of 36 cases with clinicopathologic data. Annals of Otology, Rhinology and Laryngology 84: 308314.CrossRefGoogle Scholar
Enzinger, F. M. and Weiss, S. W. (1988) Soft tissue tumours, 2nd edn, C. V. Mosby, St Louis, USA, pp 757779.Google Scholar
Michaels, L. (1984) Pathology of the Larynx, Springer Verlag, Berlin, pp 285300.CrossRefGoogle Scholar
Schottenfeld, R. and Marsh, B. (1987) Granular cell tumor of the larynx. Ear, Nose and Throat Journal 66: 415416.Google ScholarPubMed
Thunold, S., Von Eyben, F. E. and Maehle, B. (1989) Malignant granular cell tumour of the neck: immunohistochemical and ultrastructural studies. Histopathology 14: 655662.CrossRefGoogle ScholarPubMed