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Erythema multiforme after application of aural Gentisone HC drops

  • M. A. Siddiq (a1)


Erythema multiforme is an uncommon acute self-limiting condition characterized by mucocutaneous lesions of varying severity with a variable pattern of recurrence. This is a case of a four-year-old girl who developed erythema multiforme secondary to topical aural application of Gentisone HC drops (hydrocortisone acetate one per cent, gentamicin 0.3 per cent (as sulphate)) prescribed as a treatment for otorrhoea following grommet insertion. The clinical features are described and the literature reviewed. To my knowledge, this is the first reported case in the literature, of erythema multiforme secondary to a topical aminoglycoside/steroid preparation.


Corresponding author

Address for correspondence: Mr M. A. Siddiq, F.R.C.S.(Ed.), 125 Broadway, Walsall, West Midlands WS1 3HB.


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Al-Ubaidy, S. S., Nally, F. F. (1976) Erythema multiforme: Review of 26 cases. Oral Surgery, Oral Medicine and Oral Pathology 41: 601606.
Beveridge, J., Harris, M., Wise, G., Stevens, L. (1964) Long acting sulphonamides associated with Stevens-Johnson syndrome. Lancet 2: 593.
Curley, R. K., Verbov, J. L. (1986) Stevens-Johnson syndrome due to tetracyclines – a case report (doxycycline) and review of the literature. Clinical and Experimental Dermatology 12: 124125.
Gottschalk, H. R., Stone, O. J. (1976) Stevens-Johnson syndrome from ophthalmic sulfonamide. Archives of Dermatology 112: 513514.
Hebra, F. von (1866) On diseases of the skin including the exanthemata, Translated by Fagge, C.H., London (1866) New Sydenham Society. Vol. 1, pp 285289.
Huff, J. C., Weston, W. L., Tonnesan, M. G. (1983) Erythema multiforme: A critical review of characteristics, diagnostic criteria and causes. Journal of the American Academy of Dermatology 8: 763775.
Hurwitz, S. (1990)Erythema multiforme: A review of its characteristics, diagnostic criteria and management. Pediatrics in Review 11: 217222.
Kennett, S. (1968) Erythema multiforme affecting the oral cavity. Oral Surgery, Oral Medicine and Oral Pathology 25: 366373.
Lozada, F., Silverman, S. (1978) Erythema multiforme: Clinical characteristics and natural history in fifty patients. Oral Surgery, Oral Medicine and Oral Pathology 46: 628636.
Meneghini, C. L., Angelini, G. (1982) Contact dermatitis from pyrrolnitrin. Contact Dermatitis 8: 5558.
Murray, K. M., Camp, M. S. (1992) Cephalexin-induced Stevens-Johnson syndrome. Annals of Pharmacotherapy 26: 12301233.
Sarkar, S. K., Purohit, S. D., Sharma, T. N., Chawia, M. P., Gupta, D. N. (1982) Stevens-Johnson syndrome caused by streptomycin. Tubercle 63: 137138.
Schofield, J. K., Tatnall, F. M., Leigh, I. M. (1993) Recurrent erythema multiforme: clinical features and treatment in a large series of patients. British Journal of Dermatology 128: 542545.
Stevens, A. M., Johnson, F. C. (1922) A new eruptive fever associated with stomatitis and ophthalmia. American Journal of Diseases Children 24: 526533.
Stingeni, L., Caraffini, S., Assalve, D., Lapomarda, V., Lisi, P. (1996) Erythema-multiforme-like contact dermatitis from budesonide. Contact Dermatitis 34: 154155.
Thomas, B. A. (1950) The so-called Stevens Johnson syndrome. British Medical Journal 1: 13931397.
Ting, H. C., Adam, B. A. (1984) Erythema multiforme: Response to corticosteroids. Dermatologica 169: 175184.
Valsecchi, R., Tornaghi, A., Tribbia, G., Cainelli, T. (1982) Contact dermatitis from Econazole. Contact Dermatitis 8: 422.
Viraben, R., Labrousse, J. L., Bazex, J. (1990) Erythema multiforme due to DNCB. Contact Dermatitis 22: 179.


Erythema multiforme after application of aural Gentisone HC drops

  • M. A. Siddiq (a1)


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