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Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: one centre's experience

Published online by Cambridge University Press:  03 December 2009

S C Leong ,
C Kathan  and
S Mortimore
S C Leong
Affiliation:
Common Cold Centre, Cardiff University, Wales, UK
C Kathan
Affiliation:
Faculty of Economics, Administrative and Social Sciences, Bilkent University, Ankara, Turkey
S Mortimore*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Derby Hospitals National Health Service Foundation Trust, UK
*
Address for correspondence: Mr S Mortimore, Department of Otolaryngology – Head and Neck Surgery, Derby Royal Infirmary, London Road, Derby DE1 2QY, UK. Fax: 442920876986 E-mail: sean.mortimore@derbyhospitals.nhs.uk
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Abstract

Objectives:

To review early oncological outcomes following transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma.

Design:

Retrospective review of hospital electronic database.

Setting:

Large district general hospital in England, UK.

Main outcome measures:

Patients' three-year disease-specific survival and disease-free survival were evaluated, including post-operative complications, voice quality and swallowing status.

Results:

Seventy-seven patients (16 women and 61 men) were identified. Transoral laser excision of squamous cell carcinoma of the larynx was undergone by 65 patients, and the same procedure in the hypopharynx by 12. Patients with laryngeal cancer had statistically better disease-specific survival than those with hypopharyngeal cancer (p = 0.021), although the cumulative disease-free survival probability was 0.71 for both larynx and hypopharynx groups. Patients who underwent laryngectomy following failed laser treatment or as a salvage procedure had poorer outcomes.

Conclusions:

The overall results of this study were comparable with those of other, larger studies. At three-year follow up, cumulative disease-specific survival probabilities were 0.92 and 0.71 for laryngeal and hypopharyngeal squamous cell carcinoma, respectively.

Keywords

Larynx NeoplasmsPharynx NeoplasmsLaser Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 185 - 193
Copyright
Copyright © JLO (1984) Limited 2009

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