Skip to main content Accessibility help
×
Home

Diet-modified sex hormone metabolism: is this the way forward in recurrent respiratory papillamatosis and squamous carcinoma prophylaxis?

  • W. Colquhoun-Flannery (a1) and J. A. S. Carruth (a1)

Abstract

We report two cases of recurrent layngeal papillomatosis in women who subsequently developed squamous cell carcinoma as they approached the climateric. The role of human papilloma virus (HPV) and oestrogen metabolism is outlined. The use of indoles from cruciferous vegetables is also discussed.

Copyright

Corresponding author

Mr W. Colquhoun-Flannery, F.R.C.S., Department of ENT Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD.

References

Hide All
Auborn, K. J., Woodworth, C, Dipaolo, J., Bradlow, H. L. (1991) The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis. International Journal of Cancer 49: 867869.
Baron, J. A., La Vecchia, C., Levi, F. (1990) The antiestrogenic effect of cigarette smoking in women. American Journal of Obstetrics and Gynaecology 162: 502514.
Chaminadas, G., Alkhalaf, M., Remy-Martin, J. P., Propper, A. Y., Adessi, G. L. (1989) Specific effect of oestrone sulfate on protein synthesis and secretion by cultured epithelial cells from guinea-pig endometrium. Journal of Endocrinology 123: 233241.
Essman, E., Abramson, A. (1984) Estrogen-binding sites on membranes from human laryngeal papilloma. International Journal of Cancer 33: 3336.
Fishman, J., Boyar, R. M., Hellman, L. (1975) Influence of body weight on estradiol metabolism in young women. Journal of Clinical Endocrinology and Metabolism 41: 989991.
Fishman, J., Schneider, J., Hershcopf, R. J., Bradlow, H. L. (1984) Increased estrogen 16a-hydroxylase activity in women with breast and endometrial cancer. Journal of Steroid Biochemistry 20(4b): 10771088.
Galbraith, R. A., Michnovicz, J. J. (1989) The effects of cimetidine on the oxidative metabolism of estradiol. New England Journal of Medicine 321: 269274.
Hartley, C., Hamilton, J., Birzgalis, A. R., Farrington, W. T. (1994) Recurrent respiratory papillomatosis: the Manchester experience, 1974–1992. Journal of Laryngology and Otology 108: 226229.
Lindeberg, H., Syrjanen, S., Karja, J., Syrjanen, K. (1989) Human papillomavirus type 11 DNA in squamous cell carcinomas and pre-existing multiple laryngeal papillomas. Ada Otolaryngologica 107: 141149.
Lustig, R. H., Mobbs, C. V., Pfaff, D. W., Fishman, J. (1989) Temporal actions of 16a-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites between the sexes. Journal of Steroid Biochemistry 33: 417421.
Martucci, C. P., Fishman, J. (1979) Impact of continuously administered catechol estrogens in uterine growth and luteinizing hormone secretion. Endocrinology 105: 12881292.
McDanell, R., McLean, A. E. M., Hanley, A. B. (1987) Differential induction of mixed-function oxidase (MFO) activity in the rat liver and intestine by diets containing processed cabbage: correlation with cabbage levels of glucosinolates and glycosinolate hydrolysis products. Food and Chemical Toxicology 25: 363368.
Michnovicz, J. J., Bradlow, H. L. (1990) Induction of estradiol metabolism by dietary indole-3-carbinol in humans. Journal of the National Cancer Institute 82(11): 947949.
Michnovicz, J. J., Galbraith, R. A. (1990) Effects of exogenous thyroxine on C2 and C16α-hydroxylations of estradiol in humans. Steroids 55: 2226.
Michnovicz, J. J., Herschcopf, R. L., Naganuma, H., Bradlow, H. L., Fishman, J. (1986) Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigare te smoking. New England Journal of Medicine 315: 13051309.
Michnovicz, J. J., Naganuma, H., Herschcopf, R. J., Bradlow, H. L., Fishman, J. (1988) Increased urinary catechol estrogen excretion in female smokers. Steroids 52: 6983.
Moller, H., Lindvig, K., Klefter, R., Mosbech, J., Moller Jensen, O. (1989) Cancer occurrence in a cohort of patients treated with cimetidine. Gut 30: 15581562.
Mounts, P., Kashima, H. (1984) Association of human papilloma virus subtype and clinical course in respiratory papillomatosis. Laryngoscope 94: 2833.
Newfield, L., Goldsmith, A., Bradlow, H. L., Auborn, K. (1993) Estrogen metabolism and the human papillomavirusinduced tumours of the larynx: chemoprophylaxis with indole-3-carbinol. Anticancer Research 13: 337342.
Singh, B., Ramsaroop, R. (1994) Clinical features of malignant transformation in benign laryngeal papillomata. Journal of Laryngology and Otology 108: 642648.
Snow, R. C., Barbed, R. L., Frisch, R. E. (1989) Estrogen 2-hydroxylase oxidation and menstrual function among elite oarswomen. Journal of Clinical Endocrinology and Metabolism 69: 369376.
Steinberg, B. M., Auborn, K. J. (1993) Papilloma viruses in head and neck disease: pathophysiology and possible regulation. Journal of Cellular Biochemistry Supplement 17F: 155164.
Stoewsand, G.S., Anderson, J. L., Munson, L. (1988) Protective effect of dietary brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats. Cancer Letters 39: 199207.
Strong, M. S., Vaughan, C. W., Healy, G. B., Cooperbrand, S. R., Clemente, M. A. C. P. (1976) Recurrent respiratory papillomatosis. Annals of Otology, Rinology and Laryngology 85: 508516.
Swaneck, G. E., Fishman, J. (1988) Covalent binding of the endogenous 16α-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proceedings of the National Academy of Science USA 85: 78317835.
Telang, N. T., Suto, A., Wong, G. Y., Osbourne, M. R., Bradlow, H. L. (1992) Induction by estrogen metabolite 16a-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. Journal of the National Cancer Institute 84: 634663.

Keywords

Diet-modified sex hormone metabolism: is this the way forward in recurrent respiratory papillamatosis and squamous carcinoma prophylaxis?

  • W. Colquhoun-Flannery (a1) and J. A. S. Carruth (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.