Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-24T16:35:19.680Z Has data issue: false hasContentIssue false
  • English
  • Français

Diagnostic tests for immunomediated hearing loss: a systematic review

Published online by Cambridge University Press:  02 October 2007

D Lobo ,
F García López ,
J R García-Berrocal  and
R Ramírez-Camacho
D Lobo*
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
F García López
Affiliation:
Department of Epidemiology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
J R García-Berrocal
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
R Ramírez-Camacho
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
*
Address for correspondence: Dr David Lobo, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, San Martín de Porres 4 28035, Madrid, Spain. Fax:  + 34913730535 E-mail: d.lobo@excite.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To quantitatively evaluate the diagnostic accuracy of diagnostic tests for immunomediated hearing loss.

Data sources:

We searched Medline and the Cochrane Database of Systematic Reviews for potentially relevant studies.

Study selection:

Twenty-five studies met the inclusion criteria of this systematic review. The diagnosis of immunomediated hearing loss was based on the clinical presentation and the response to corticosteroid administration.

Data extraction:

The following data were extracted from the selected studies and entered into a standardised database: population demographics; exclusion and inclusion criteria; diagnostic tests; sensitivity; specificity; the number of true positive, true negative, false positive and false negative values; therapy used, including dose and duration; and delay between symptom onset and therapy commencement.

Data synthesis:

This systematic review combined data from 679 patients with immunomediated hearing loss, reported by 22 research teams. Substantial heterogeneity was found among the included studies; for this reason, summary sensitivity and specificity values were not computed.

Conclusions:

The results of diagnostic tests for immunomediated hearing loss depend on many factors, and there is a risk of potential bias. This is the first time that such a systematic review has been presented; such a review is a more rigorous method of demonstrating the utility of the available diagnostic tests.

Keywords

AutoimmunityInner EarVestibular DisordersSensorineural Deafness
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 6 , June 2008 , pp. 564 - 573
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 McCabe, BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979;88:585–9CrossRefGoogle ScholarPubMed
2 Mulrow, CD. The medical review article: state of the science. Ann Intern Med 1987;106:485–8CrossRefGoogle ScholarPubMed
3 Greenhalgh, T. How to read a paper: papers that summarize other papers (systematic reviews and meta-analyses). BMJ 1997;315:672–5CrossRefGoogle Scholar
4 Irwig, L, Tosteson, AN, Gatsonis, C, Lau, J, Colditz, G, Chalmers, TC et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med 1994;120:667–76CrossRefGoogle ScholarPubMed
5 Deville, WL, Buntinx, F, Bouter, LM. Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Med Res Methodol 2002;2:9–21CrossRefGoogle ScholarPubMed
6 Agrup, C, Luxon, LM. Immune-mediated inner-ear disorders in neuro-otology. Curr Opin Neurol 2006;19:26–32CrossRefGoogle ScholarPubMed
7 Soliman, AM. Immune-mediated inner ear disease. Am J Otol 1992;13:575–9Google ScholarPubMed
8 Ryan, AF, Harris, JP, Keithley, EM. Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Suppl 2002;548:38–43CrossRefGoogle Scholar
9 Veldman, J. Immune-mediated sensorineural hearing loss. Auris Nasus Larynx 1998;25:309–17CrossRefGoogle ScholarPubMed
10 Barna, BP, Hughes, GB. Autoimmune inner ear disease – a real entity? Clin Lab Med 1997;17:581–94CrossRefGoogle ScholarPubMed
11 Plester, D, Soliman, AM. Autoimmune hearing loss. Am J Otol 1989;10:188–92Google ScholarPubMed
12 Hughes, GB, Barna, BP, Kinney, SE, Calabrese, SH, Nalepa, NL. Predictive value of laboratory tests in “autoimmune” inner ear disease: preliminary report. Laryngoscope 1986;96:502–5CrossRefGoogle ScholarPubMed
13 Hughes, GB, Moscicki, R, Barna, BP, San Martin, JE. Laboratory diagnosis of immune inner ear disease. Am J Otol 1994;15:198–202Google ScholarPubMed
14 Harris, JP. Autoimmunity of the inner ear. Am J Otol 1989;10:193–5Google ScholarPubMed
15 Soliman, AM. Experimental autoimmune inner ear disease. Laryngoscope 1989;99:188–93CrossRefGoogle ScholarPubMed
16 Veldman, JE. Immunology of hearing: experiments of nature. Am J Otol 1989;10:183–7Google ScholarPubMed
17 Harris, JP, Heydt, J, Keithley, EM, Chen, MC. Immunopathology of the inner ear: an update. Ann NY Acad Sci 1997;830:166–78CrossRefGoogle ScholarPubMed
18 Ruckenstein, MJ, Milburn, M, Hu, L. Strial dysfunction in the MRL-Fas mouse. Otolaryngol Head Neck Surg 1999;121:452–6CrossRefGoogle ScholarPubMed
19 García-Berrocal, JR, Ramírez-Camacho, R, Trinidad, A, Zurita, M, de la Fuente, R, Lobo, D. Controversies and criticisms on designs for experimental autoimmune labyrinthitis. Ann Otol Rhinol Laryngol 2004;113:404–10CrossRefGoogle ScholarPubMed
20 Yoo, TJ, Tomoda, K, Stuart, JM, Cremer, MA, Townes, AS, Kang, AH. Type II collagen –induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats [in Italian]. Ann Otol Rhinol Laryngol 1983;92:267–71CrossRefGoogle ScholarPubMed
21 Cadoni, G, Fetoni, AR, Agostino, S. Role of endothelial cell autoantibodies in the pathogenesis of sudden hearing loss. Acta Otorhinolaryngol Ital 2001;21:138–43Google Scholar
22 Lake, GM 3rd, Sismanis, A, Ariga, T, Yamawaki, M, Gao, Y, Yu, RK. Antibodies to glycosphingolipid antigens in patients with immune-mediated cochleovestibular disorders. Am J Otol 1997;18:175–8Google ScholarPubMed
23 Cao, MY, Dupriez, VJ, Rider, MH, Deggouj, N, Gersdorff, MC, Rousseau, GG et al. Myelin protein Po as a potential autoantigen in autoimmune inner ear disease. FASEB J 1996;10:1635–40CrossRefGoogle Scholar
24 Zajic, G, Nair, TS, Ptok, M, Van Waes, C, Altschuler, RA, Schacht, J et al. Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells of guinea pig cochlea. Hear Res 1991;52:59–71CrossRefGoogle ScholarPubMed
25 Ptok, M, Nair, TS, Altschuler, RA, Schacht, J, Carey, TE Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia. Hear Res 1991;57:79–90CrossRefGoogle ScholarPubMed
26 Suzuki, M, Krug, MS, Cheng, KC, Yazawa, Y, Bernstein, J, Yoo, TJ. Antibodies against inner ear proteins in the sera of patients with inner-ear diseases. ORL J Otorhinolaryngol Relat Spec 1997;59:10–17CrossRefGoogle ScholarPubMed
27 Hefeneider, SH, McCoy, SL, Hausman, FA, Trune, DR. Autoimmune mouse antibodies recognize multiple antigens proposed in human immune-mediated hearing loss. Otol Neurotol 2004;25:250–6CrossRefGoogle ScholarPubMed
28 Boulassel, MR, Tomasi, JP, Deggouj, N, Gersdorff, M. Identification of β-actin as a candidate autoantigen in autoimmune inner ear disease. Clin Otolaryngol 2000;25:535–41CrossRefGoogle ScholarPubMed
29 Nair, TS, Prieskorn, DM, Miller, JM, Mori, A, Gray, J, Carey, TE. In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody. Hear Res 1997;107:93–101CrossRefGoogle ScholarPubMed
30 Garcia-Berrocal, JR. Inmunomediated inner ear disease [in Spanish]. Barcelona: Ars Medica, 2004;59–70Google Scholar
31 Harris, JP, Sharp, PA. Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing loss. Laryngoscope 1990;100:319–25CrossRefGoogle ScholarPubMed
32 Gong, SS, Yu, DZ, Wang, JB. Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease. Acta Otolaryngol 2002;122:5–9CrossRefGoogle ScholarPubMed
33 Yamanobe, S, Harris, JP. Inner ear specific antibodies. Laryngoscope 1998;103:319–25CrossRefGoogle Scholar
34 Cao, MY, Deggoug, N, Gersdorff, M, Tomasi, JP. Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. Laryngoscope 1996;106:207–12CrossRefGoogle Scholar
35 Nair, TS, Kozma, KE, Hoefling, NL, Kommareddi, PK, Ueda, Y, Gong, TW et al. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa, that is the target of antibody-induced hearing loss. J Neurosci 2004;18:1772–9CrossRefGoogle Scholar
36 Hughes, GB, Barna, BP, Kinney, SE, Calabrese, LH, Nalepa, NJ. Clinical diagnosis of immune inner-ear disease. Laryngoscope 1988;98:251–3CrossRefGoogle ScholarPubMed
37 Kanzaki, J. Diagnostic criteria for acute profound deafness. Acta Otolaryngol (Stockh) Suppl 1994;514:7–8CrossRefGoogle ScholarPubMed
38 Garcia-Berrocal, JR, Ramirez-Camacho, R, Millan, I. Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction. J Laryngol Otol 2003;117:775–9CrossRefGoogle ScholarPubMed
39 Brookes, GB. Immune-complex associated deafness: preliminary communication. J Roy Soc Med 1985;78:47–55CrossRefGoogle ScholarPubMed
40 Kempf, HG, Hornig, T. Immunologic findings and therapeutic results in chronic progressive inner ear hearing loss [in German]. HNO 1987;35:38–42Google ScholarPubMed
41 Hughes, GB, Barna, BP, Kinney, SE, Calabrese, LH, Nalepa, NJ. Clinical diagnosis of immune inner-ear disease. Laryngoscope 1988;98:251–3CrossRefGoogle ScholarPubMed
42 Helfgott, SM, Moscicki, RA, San Martin, J, Lorenzo, C, Kieval, R, McKenna, M et al. Correlation between antibodies to type II collagen and treatment outcome in bilateral progressive sensorineural hearing loss. Lancet 1991;337:387–9CrossRefGoogle ScholarPubMed
43 Lejeune, JM, Charachon, R. Value of immunobiological tests in Meniere's disease and in rapidly progressive sensorineural deafness [in French]. Rev Laryngol Otol Rhinol (Bord) 1991;112:127–31Google ScholarPubMed
44 Veldman, JE, Handa, T, Meeuwsen, F. Diagnostic dilemmas in rapidly progressive sensorineural hearing loss and sudden deafness. Acta Otolaryngol (Stockh) 1993;113:303–6CrossRefGoogle ScholarPubMed
45 Cotter, CS, Singleton, GT, Corman, LC. Immune-mediated inner ear disease and parvovirus B19. Laryngoscope 1994;104:1235–9CrossRefGoogle ScholarPubMed
46 Kanzaki, J, Inoue, Y, O-uchi, T. Immunological findings of serological test in steroid-responsive sensorineural hearing loss. Acta Otolayngol (Stockh) 1994;514:66–9CrossRefGoogle Scholar
47 Moscicki, RA, San Martin, JE, Quintero, CH, Rauch, SD, Nadol, JB Jr, Bloch, KJ. Serum antibody to inner ear proteins in patients with progressive hearing loss. JAMA 1994;272:611–16CrossRefGoogle ScholarPubMed
48 García-Berrocal, JR, Pinilla, M, Ramírez-Camacho, R, González, M, López-Cortijo, C. Inner ear diseases of probable autoimmune origin and their response to steroid treatment [in Spanish]. Acta Otorrinolaringol Esp 1995;46:416–20Google ScholarPubMed
49 Rauch, SD, San Martin, JE, Moscicki, RA, Bloch, KJ. Serum antibodies against heat shock protein 70 in Meniere's disease. Am J Otol 1995;16:648–52Google ScholarPubMed
50 Disher, MJ, Ramakrishnan, A, Nair, TS, Miller, JM, Telian, SA, Arts, HA et al. Human autoantibodies and monoclonal antibody KHRI-3 bind to a philogenetically conserved inner-ear-supporting cell antigen. Ann N Y Acad Sci 1997;830:253–65CrossRefGoogle Scholar
51 Quaranta, A, Scaringi, A, Portalatini, P, Vantaggiato, D. Auditory findings in subjects with immunomediated sensorineural hearing loss. Ann N Y Acad Sci 1997;830:277–90CrossRefGoogle ScholarPubMed
52 Yamawaki, M, Ariga, T, Gao, Y, Tokuda, A, Yu, JS, Sismanis, A et al. Sulfoglucuronosyl glycolipids as putative antigens for autoimmune inner ear disease. J Neuroimmunol 1998;84:111–16CrossRefGoogle ScholarPubMed
53 Hirose, K, Wener, MH, Duckert, LG. Utility of laboratory testing in autoimmune inner ear disease. Laryngoscope 1999;109:1749–54CrossRefGoogle ScholarPubMed
54 Zavod, MB, Sataloff, RT, Vijay, MR. Frequency of cochlear enhancement on magnetic resonance imaging in patients with autoimmune sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 2000;126:969–71CrossRefGoogle ScholarPubMed
55 Lunardi, C, Bason, C, Leandri, M, Navone, R, Lestani, M, Millo, E et al. Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome. Lancet 2002;360:915–21CrossRefGoogle ScholarPubMed
56 Lorenz, RR, Solares, CA, Williams, P, Sikora, J, Pelfrey, CM, Hughes, GB et al. Interferon-γ production to inner ear antigens by T cells from patients with autoimmune sensorineural hearing loss. J Neuroimmunol 2002;130:173–8CrossRefGoogle Scholar
57 García-Berrocal, JR, Ramírez-Camacho, R, Vargas, JA, Millan, I. Does the serological testing really play a role in the diagnosis immune-mediated inner ear disease? Acta Otolaryngol 2002;122:243–8CrossRefGoogle ScholarPubMed
58 Cadoni, G, Fetoni, AR, Agostino, S, De Santis, A, Manna, R, Ottaviani, F et al. Autoimmunity in sudden sensorineural hearing loss: possible role of anti-endothelial cell autoantibodies. Acta Otolaryngol 2002;548:30–3CrossRefGoogle Scholar
59 García Callejo, FJ, Marco Algarra, J, Martínez Beneyto, MP, Orts Alborch, MH, Morant Ventura, A. Autoimmune identification of sudden hearing loss. Acta Otolaryngol 2003;123:168–71CrossRefGoogle ScholarPubMed
60 Mazlumzadeh, M, Lowe, VJ, Mullan, BP, Fabry, DA, McDonald, TJ, Matteson, EL. The utility of positron emission tomography in the evaluation of autoimmune hearing loss. Otol Neurotol 2003;24:201–4CrossRefGoogle ScholarPubMed
61 Loveman, DM, de Comarmond, C, Cepero, R, Baldwin, DM. Autoimmune sensorineural hearing loss: clinical course and treatment outcome. Semin Arthritis Rheum 2004;34:538–43CrossRefGoogle ScholarPubMed
62 Zeitoun, H, Beckman, JG, Arts, HA, Lansford, CD, Lee, DS, El-Kashlan, HK et al. Corticosteroid response and supporting cell antibody in autoimmune hearing loss. Arch Otolaryngol Head Neck Surg 2005;131:665–72CrossRefGoogle ScholarPubMed
63 Zamora, J, Abraira, V, Muriel, A, Khan, K, Coomarasamy, A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31–42CrossRefGoogle ScholarPubMed
64 Whiting, P, Rutjes, AW, Reitsma, JB, Glas, AS, Bossuyt, PM, Kleijnen, J. Sources of variation and bias in studies of diagnostic accuracy: a systematic review. Ann Intern Med 2004;140:189–202CrossRefGoogle ScholarPubMed
65 Munari, L, Charchat, S, Rodrigues, L, von Muhlen, CA, Bau, AR, Lavinsky, L et al. An ELISA serum assay for autoantibodies to HSP70 in immune-mediated hearing loss. J Immunol Methods 2003;283:155–61CrossRefGoogle ScholarPubMed
66 García-Berrocal, JR, Ramírez-Camacho, R, Arellano, B, Vargas, JA. Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease. Laryngoscope 2002;112:304–9CrossRefGoogle ScholarPubMed
67 Goehring, C, Perrier, A, Morabia, A. Spectrum bias: a quantitative and graphical analysis of the variability of medical diagnostic test performance. Stat Med 2004;15:23:125–35Google Scholar
68 Mulherin, SA, Miller, WC. Spectrum bias or spectrum effect? Subgroup variation in diagnostic test evaluation. Ann Intern Med 2002;137:598–602CrossRefGoogle ScholarPubMed
69 Read, MC, Lachs, MS, Feinstein, AR. Use of methodological standards in diagnostic test research: getting better but still not good. JAMA 1995;274:645–51CrossRefGoogle Scholar
70 Broughton, SS, Meyerhoff, WE, Cohen, SB. Immune-mediated inner ear disease: 10-year experience. Semin Arthritis Rheum 2004;34:544–8CrossRefGoogle Scholar
71 Lasak, JM, Sataloff, RT, Hawkshaw, M, Carey, TE, Lyons, KM, Spiegel, JR. Autoimmune inner ear disease: steroid and cytotoxic drug therapy. Ear Nose Throat J 2001;80:808–18CrossRefGoogle ScholarPubMed
72 Ruckenstein, MJ. Autoimmune inner ear disease. Curr Opin Otolaryngol Head Neck Surg 2004;12:426–30CrossRefGoogle ScholarPubMed
73 Harris, JP, Weisman, MH, Derebery, JM, Espeland, MA, Gantz, BJ, Gulya, AJ et al. Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate: a randomized controlled trial. JAMA 2003;290:1875–83CrossRefGoogle ScholarPubMed
74 Cohen, S, Shoup, A, Weisman, MH, Harris, J. Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study. Otol Neurotol 2005;26:903–7CrossRefGoogle ScholarPubMed
75 Lobo, D, Trinidad, A, García-Berrocal, JR, Verdaguer, JM, Ramírez-Camacho, R. TNF alpha blockers do not improve the hearing recovery obtained with glucocorticoid therapy in an autoimmune experimental labyrinthitis. Eur Arch Otorhinolaryngol 2006;263:622–6CrossRefGoogle ScholarPubMed