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Cryoglobulinaemia and septal perforation: a rare but logical cause

  • I. Smith (a1), M. Smith (a1), D. Mathias (a1) and J. Wallis (a2)

Abstract

A case of nasal septal perforation secondary to cryoglobulinaemia is reported. In this instance the cryoglobulinaemia was due to Waldenstrom's macroglobulinaemia (lymphoplasmocytic lymphoma with IgM paraprotein) in which the paraprotein was a potent cryoglobulin.

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Corresponding author

Address for correspondence: Mr I. Smith, ENT Department, Leeds General Infirmary, Great George Street, Leeds LSI 3EX.

References

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Brain, D. (1987) Nasal septum. In Scott Brown's Otolaryngology. 5th Edition. (Mackay, I. S., Bull, T. R., Kerr, A. G., eds.). Vol. 4, Butterworth and Co., London, p 170.
Chapel, H., Heaney, M. (1989) Essentials of Clinical Immunology, 2nd Edition, Blackwell Scientific, Oxford, p 270.
De Grunchy, G. C. (1989) Clinical Haematology in Medical Practice. 5th Edition. (Firkin, F., Chesterman, C., Penington, D., Rush, B., eds.) Blackwell Scientific, Oxford, p 303.
Dammacco, F., Miglietta, A., Lobreglio, G., Bonomo, L. (1986) Cryoglobulins and pyroglobulins: an overview. [Review]. Ricerca in Clinica e in Laboratorio 16(2): 247267.
Invernizzi, F., Galli, M., Serino, G., Monti, G., Meroni, P. L., Granatieri, C., Zanussi, C. (1983) Secondary and essential cryoglobulinaemias. Frequency, nosological classification, and long-term follow-up. Acta Haematologica 70(2): 7382.

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