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Correlation between liver cirrhosis and risk of death from oral cancer: Taiwan cohort study

  • K-P Chang (a1) (a2) (a3), C-C Lee (a1) (a2) (a3), Y-C Su (a4), M-L Han (a5), T-H Kung (a5) and H-J Chang (a6)...



A nationwide population-based cohort was used to examine the severity of liver cirrhosis and risk of mortality from oral cancer.


The cohort consisted of 3583 patients with oral cancer treated by surgery between 2008 and 2011 in Taiwan. They were grouped on the basis of normal liver function (n = 3471), cirrhosis without decompensation (n = 72) and cirrhosis with decompensation (n = 40). The primary endpoint was mortality. Hazard ratios of death were also determined.


The mortality rates in the respective groups were 14.8 per cent, 20.8 per cent and 37.5 per cent at one year (p < 0.001). The adjusted hazard ratios of death at one year for each group compared to the normal group were 2.01 (p = 0.021) for cirrhotic patients without decompensation, 4.84 (p < 0.001) for those with decompensation and 2.65 (p < 0.001) for those receiving chemotherapy.


Liver cirrhosis can be used to predict one-year mortality in oral cancer patients. Chemotherapy should be used with caution and underlying co-morbidities should be managed in cirrhotic patients to reduce mortality risk.


Corresponding author

Address for correspondence: Dr Heng-Jui Chang, Department of Radiation Oncology, Min-Sheng General Hospital, Taoyuan, Taiwan No. 168, Jingguo Rd, Taoyuan Dist, Taoyuan City 330, Taiwan E-mail:


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