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Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma

  • V S Nesic (a1) (a2), Z M Petrovic (a1) (a2), S B Sipetic (a3), S D Jesic (a1) (a2), I A Soldatovic (a4) and D A Kastratovic (a5)...

Abstract

Objective:

This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.

Methods:

The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.

Results:

On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour–node–metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.

Conclusion:

The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.

Copyright

Corresponding author

Address for correspondence: Dr Vladimir S Nesic, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia Fax: +381 112418217 E-mail: snesic@sbb.rs

References

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1Kaplan, MH, Feinstein, AR. The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 1974;27:387404
2Charlson, ME, Pompei, P, Ales, KL, MacKenzie, CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83
3Piccirillo, JF, Wells, CK, Sasaki, CT, Feinstein, AR. New clinical severity staging system for cancer of the larynx. Ann Otol Rhinol Laryngol 1994;103:8392
4Linn, BS, Linn, MW, Lee, G. Cumulative illness rating scale. J Am Geriatr Soc 1968;5:622–6
5Greenfield, S, Apolone, G, McNeil, BJ, Cleary, PD. The importance of co-existent disease in the occurrence of postoperative complications and one-year recovery in patients undergoing total hip replacement. Comorbidity and outcomes after hip replacement. Med Care 1993;31:141–54
6Klabunde, CN, Potosky, AL, Legler, JM, Warren, JL. Development of a comorbidity index using physician claims data. J Clin Epidemiol 2000;53:1258–67
7Piccirillo, JF, Creech, CM, Zequeira, R, Anderson, S, Johnston, AS. Inclusion of comorbidity into oncology data registries. Journal of Registry Management 1999;26:6670
8Piccirillo, JF. Importance of comorbidity in head and neck cancer. Laryngoscope 2000;110:593602
9Paleri, V, Wight, RG, Davies, GR. Impact of comorbidity on the outcome of laryngeal squamous cancer. Head Neck 2003;25:1019–26
10Castro, MA, Dedivitis, RA, Ribeiro, KC. Comorbidity measurement in patients with laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 2007;69:146–52
11Chen, AY, Matson, LK, Roberts, D, Goepfert, H. The significance of comorbidity in advanced laryngeal cancer. Head Neck 2001;23:566–72
12Piccirillo, JF, Lacy, PD, Basu, A, Spitznagel, EL. Development of a new head and neck cancer-specific comorbidity index. Arch Otolaryngol Head Neck Surg 2002;128:1172–9
13Cleves, MA, Sanchez, N, Draheim, M. Evaluation of two competing methods for calculating Charlson's comorbidity index when analyzing short-term mortality using administrative data. J Clin Epidemiol 1997;50:903–8
14Sabin, SL, Rosefeld, RM, Sundaram, K, Har-El, G, Lucente, FE. The impact of comorbidity and age on survival with laryngeal cancer. Ear Nose Throat J 1999;78:578, 581–4
15Head and Neck. In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn.New York: Springer, 2010;5768
16Datema, FR, Ferrier, MB, van der Schroeff, MP, Baatenburg de Jong, RJ. Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck 2010;32:728–36
17Paleri, V, Narayan, R, Wight, RG. Descriptive study of the type and severity of decompensation caused by comorbidity in a population of patients with laryngeal squamous cancer. J Laryngol Otol 2004;118:517–21
18Singh, B, Bhaya, M, Zimbler, M, Stern, J, Roland, JT, Rosenfeld, RM et al. Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma. Head Neck 1998;20:17
19Singh, B, Bhaya, M, Stern, J, Roland, JT, Zimbler, M, Rosenfeld, RM et al. Validation of the Charlson comorbidity index in patients with head and neck cancer: a multi-institutional study. Laryngoscope 1997;107:1469–75
20Paleri, V, Wight, RG. Applicability of the Adult Comorbidity Evaluation - 27 and the Charlson indexes to assess comorbidity by notes extraction in a cohort of United Kingdom patients with head and neck cancer: a retrospective study. J Laryngol Otol 2002;116:200–5
21Hall, SF, Rochon, PA, Streiner, DL, Paszat, LF, Groome, PA, Rohland, SL. Measuring comorbidity in patients with head and neck cancer. Laryngoscope 2002;112:1988–96
22Piccirillo, JF, Spitznagel, EL Jr, Vermani, N, Costas, I, Schnitzler, M. Comparison of comorbidity indices for patients with head and neck cancer. Med Care 2004;42:482–6
23Montero, EH, Trufero, JM, Romeo, JA, Terré, FC. Comorbidity and prognosis in advanced hypopharyngeal-laryngeal cancer under combined therapy. Tumori 2008;94:24–9
24Cascorbi, I. The promises of personalized medicine. Eur J Clin Pharmacol 2010;66:749–54
25Paleri, V, Wight, RG. A cross-comparison of retrospective notes extraction and combined notes extraction and patient interview in the completion of a comorbidity index (ACE-27) in a cohort of United Kingdom patients with head and neck cancer. J Laryngol Otol 2002;116:937–41

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