Hostname: page-component-7479d7b7d-t6hkb Total loading time: 0 Render date: 2024-07-12T00:58:30.702Z Has data issue: false hasContentIssue false

Cocaine-associated Eustachian tube stenosis causing chronic ‘glue ear’: a rare cocaine-induced destructive lesion

Published online by Cambridge University Press:  08 February 2024

Talib Dar*
Affiliation:
ENT Department, Luton and Dunstable University Hospital, Luton, UK
Michel Abou-Abdallah
Affiliation:
ENT Department, Luton and Dunstable University Hospital, Luton, UK
Joshua Michaels
Affiliation:
ENT Department, Luton and Dunstable University Hospital, Luton, UK
Rishi Talwar
Affiliation:
ENT Department, Luton and Dunstable University Hospital, Luton, UK
*
Corresponding author: Talib Dar; Email: talib.dar@nhs.net

Abstract

Background

Cocaine is one of the most used recreational drugs. Whilst medical uses exist, chronic recreational nasal use of cocaine is associated with progressive destruction of the osseocartilaginous structures of the nose, sinuses and palate – termed cocaine-induced midline destructive lesions.

Case report

A 43-year-old male with a history of chronic cocaine use, presented with conductive hearing loss and unilateral middle-ear effusion. Examination under anaesthesia revealed a completely stenosed left Eustachian tube orifice with intra-nasal adhesions. The adhesions were divided and the hearing loss was treated conservatively with hearing aids. Whilst intra-nasal cocaine-induced midline destructive lesions are a well-described condition, this is the first known report of Eustachian tube stenosis associated with cocaine use.

Conclusion

This unique report highlights the importance of thorough history-taking, rhinological and otological examination, and audiometric testing when assessing patients with a history of chronic cocaine use. This paper demonstrates the complexity of managing hearing loss in such cases, with multiple conservative and surgical options available.

Type
Clinical Records
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Talib Dar takes responsibility for the integrity of the content of the paper

References

Perez Alamino, R, Espinoza, LR. Vasculitis mimics: cocaine-induced midline destructive lesions. Am J Med Sci 2013;346:430–110.1097/MAJ.0b013e3182972014CrossRefGoogle ScholarPubMed
Trimarchi, M, Gregorini, G, Facchetti, F, Morassi, ML, Manfredini, C, Maroldi, R et al. Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic, and serologic features and their differentiation from Wegener granulomatosis. Medicine (Baltimore) 2001;80:39140410.1097/00005792-200111000-00005CrossRefGoogle ScholarPubMed
Barbotti, A, Gheorghiu, AC, Fusi-Schmidhauser, T, Grazioli-Gauthier, L. Leukocytoclastic vasculitis induced by cocaine adulterated with levamisole. Eur J Case Rep Intern Med 2022;9:003468Google ScholarPubMed
Pessini, LM, Kremer, S, Auger, C, Castillo, J, Pottecher, J, de Seze, J et al. Tumefactive inflammatory leukoencephalopathy in cocaine users: report of three cases. Mult Scler Relat Disord 2020;38:10149610.1016/j.msard.2019.101496CrossRefGoogle ScholarPubMed
Goerig, M, Bacon, D, van Zundert, A. Carl Koller, cocaine, and local anesthesia: some less known and forgotten facts. Reg Anesth Pain Med 2012;37:318–2410.1097/AAP.0b013e31825051f3CrossRefGoogle Scholar
Lutfallah, SC, Brown, E, Spillers, NJ, Tandon, A, Kelkar, RA, Ahmadzadeh, S et al. Topical cocaine hydrochloride nasal solution: anesthetic and surgical considerations. Cureus 2023;15:e42804Google ScholarPubMed
Businco, LD, Lauriello, M, Marsico, C, Corbisiero, A, Cipriani, O, Tirelli, GC. Psychological aspects and treatment of patients with nasal septal perforation due to cocaine inhalation. Acta Otorhinolaryngol Ital 2008;28:247–51Google ScholarPubMed
Sittel, C, Eckel, HE. Nasal cocaine abuse presenting as a central facial destructive granuloma. Eur Arch Otorhinolaryngol 1998;255:446–710.1007/s004050050096CrossRefGoogle ScholarPubMed
Subesinghe, S, van Leuven, S, Yalakki, L, Sangle, S, D'Cruz, D. Cocaine and ANCA associated vasculitis-like syndromes – a case series. Autoimmun Rev 2018;17:73–710.1016/j.autrev.2017.11.011CrossRefGoogle ScholarPubMed
Trimarchi, M, Bussi, M, Sinico, RA, Meroni, P, Specks, U. Cocaine-induced midline destructive lesions – an autoimmune disease? Autoimmun Rev 2013;12:49650010.1016/j.autrev.2012.08.009CrossRefGoogle ScholarPubMed
Colletti, G, Autelitano, L, Chiapasco, M, Biglioli, F, Giovanditto, F, Mandala, M et al. Comprehensive surgical management of cocaine-induced midline destructive lesions. J Oral Maxillofac Surg 2014;72:1395.e1–1010.1016/j.joms.2014.03.013CrossRefGoogle ScholarPubMed
Lancaster, J, Belloso, A, Wilson, CA, McCormick, M. Rare case of naso-oral fistula with extensive osteocartilaginous necrosis secondary to cocaine abuse: review of otorhinolaryngological presentations in cocaine addicts. J Laryngol Otol 2000;114:630–310.1258/0022215001906345CrossRefGoogle ScholarPubMed
Millard, DR, Mejia, FA. Reconstruction of the nose damaged by cocaine. Plast Reconstr Surg 2001;107:419–2410.1097/00006534-200102000-00018CrossRefGoogle ScholarPubMed
Molteni, M, Saibene, AM, Luciano, K, Maccari, A. Snorting the clivus away: an extreme case of cocaine-induced midline destructive lesion. BMJ Case Rep 2016;2016:bcr201621639310.1136/bcr-2016-216393CrossRefGoogle ScholarPubMed
Bacciu, A, Ghirelli, M, Ingegnoli, A, Bozzetti, F. Cocaine-induced midline destructive lesions associated with erosion of the Eustachian tube. JAMA Otolaryngol Head Neck Surg 2018;144:846–810.1001/jamaoto.2018.1387CrossRefGoogle ScholarPubMed
Nitro, L, Pipolo, C, Fadda, GL, Allevi, F, Borgione, M, Cavallo, G et al. Distribution of cocaine-induced midline destructive lesions: systematic review and classification. Eur Arch Otorhinolaryngol 2022;279:3257–6710.1007/s00405-022-07290-1CrossRefGoogle Scholar
Kuriloff, DB, Kimmelman, CP. Osteocartilaginous necrosis of the sinonasal tract following cocaine abuse. Laryngoscope 1989;99:918–2410.1288/00005537-198909000-00005CrossRefGoogle ScholarPubMed
Trimarchi, M, Bondi, S, Della Torre, E, Terreni, MR, Bussi, M. Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis. Acta Otorhinolaryngol Ital 2017;37:281–510.14639/0392-100X-1586CrossRefGoogle ScholarPubMed
Westreich, RW, Lawson, W. Midline necrotizing nasal lesions: analysis of 18 cases emphasizing radiological and serological findings with algorithms for diagnosis and management. Am J Rhinol 2004;18:209–1910.1177/194589240401800405CrossRefGoogle ScholarPubMed
Seyer, BA, Grist, W, Muller, S. Aggressive destructive midfacial lesion from cocaine abuse. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:465–7010.1067/moe.2002.126020CrossRefGoogle ScholarPubMed
Bluestone, CD, Doyle, WJ. Anatomy and physiology of eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol 1988;81:997100310.1016/0091-6749(88)90168-6CrossRefGoogle ScholarPubMed
Sade, J, Ar, A. Middle ear and auditory tube: middle ear clearance, gas exchange, and pressure regulation. Otolaryngol Head Neck Surg 1997;116:49952410.1016/S0194-59989770302-4CrossRefGoogle ScholarPubMed
Silverstein, H, Light, JP, Jackson, LE, Rosenberg, SI, Thompson, JH Jr. Direct application of dexamethasone for the treatment of chronic eustachian tube dysfunction. Ear Nose Throat J 2003;82:283210.1177/014556130308200110CrossRefGoogle ScholarPubMed