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Clear cell carcinoma arising in a pleomorphic adenoma of the submandibular gland

Published online by Cambridge University Press:  29 June 2007

Michael Cassidy  and
Charles E. Connolly
Michael Cassidy*
Affiliation:
Department of Pathology, Royal College of Surgeons in Ireland
Charles E. Connolly
Affiliation:
Department of Histopathology and Cytology, University College Hospital, Galway, Ireland.
*
Dr Michael Cassidy, Department of Pathology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland. Fax: 01-4780200
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Abstract

Clear cell carcinoma of salivary gland is a rare neoplasm. We report a third case of clear cell carcinoma arising in a pleomorphic adenoma and also in an extraparotid location. We document the immunohistochemical profile of the tumour including reactivity with a marker for the c-erbh-2 oncoprotein and suggest a myoepithelial origin for these lesions. The presence of a tetraploid stemline may account for the rapid tumour progression in this case.

Keywords

Salivary gland neoplasmsCarcinoma, clear cellPloidies
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 6 , June 1994 , pp. 529 - 532
Copyright
Copyright © JLO (1984) Limited 1994

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References

Betta, P. G., Robutti, F., Spinoglio, G., Bottero, G. (1988) Uncommon histological variants of clear cell carcinoma of the ovary. European Journal of Gynaecological Oncology 9: 431–434.Google ScholarPubMed
Chen, K. T. K. (1983) Clear cell carcinoma of the salivary glands. Human Pathology 13: 91–93.CrossRefGoogle Scholar
Coombs, L. M., Pigott, D. A., Sweeney, E. (1991) Amplification and overexpression of c-erbB-2 in transitional cell carcinoma of urinary bladder. British Journal of Cancer 63: 601–608.CrossRefGoogle Scholar
De Araujo, V. C., de Araujo, N. S. (1990) Vimentin as a marker of myoepithelial cells in salivary gland tumours. European Archives of Otorhinolaryngology 247: 252–255.CrossRefGoogle Scholar
El-Naggar, A., Batsakis, J. G., Luna, M. A., Goepfert, H., Tortoledo, M. E. (1989) DNA content and proliferative activity of myoepitheliomas. Journal of Laryngology and Otology 103: 1192–1197.CrossRefGoogle ScholarPubMed
Franzen, G., Klausen, O. G., Grenko, R. T., Carstensen, J., Nordenskjold, B. (1991) Adenoid cystic carcinoma: DNA as a prognostic indicator. Laryngoscope 101: 669–673.CrossRefGoogle ScholarPubMed
Gustaffson, H., Virtanen, I., Thornell, L. E. (1989) Glial fibrillary acidic protein and desmin in salivary neoplasms. Expression of four different types of intermediate filament proteins within the same cell type. Virchows Archiv. B: Cell Pathology 57: 303–313.CrossRefGoogle Scholar
Hamper, K., Brugmann, M., Caselitz, J., Arps, H., Berger, J., Askensten, V., Auer, G., Seijert, G. (1989) Prognosis of salivary adenocarcinomas. A retrospective study of 52 cases with special regard to cytochemically-assessed nuclear DNA content. Virchows Archiv. A: Pathological Anatomy and Histopathology 416: 57–64.CrossRefGoogle ScholarPubMed
Hedley, D. W., Friedlander, M. L., Taylor, I. W., Rigg, C. A., Musgrove, E. A. (1983) Method of analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. Journal of Histochemistry and Cytochemistry 31: 1333–1335.CrossRefGoogle ScholarPubMed
Kernohan, N. M., Blessing, K., King, G., Corbett, I. P., Miller, I. D. (1991) Expression of C-erbB-2 oncoprotein in salivary gland tumours: an immunohistochemical study. Journal of Pathology 163: 77–80.CrossRefGoogle ScholarPubMed
Klijanienko, J., Micheau, C., Schwaab, G., Marandas, P., Friedman, S. (1989) Clear cell carcinoma arising in pleomorphic adenoma of the minor salivary gland. Journal of Laryngology and Otology 103: 789–791.CrossRefGoogle ScholarPubMed
Listinsky, C. M., Bonfiglio, T. A., Leary, J. (1988) Variable ploidy of ovarian clear cell carcinomas. Implications for adequacy of tissue sampling. Analytical and Quantitative Cytology and Histology 10: 21–27.Google ScholarPubMed
Littman, C. D., Alguacil-Garcia, A. (1987) Clear cell carcinoma arising in pleomorphic adenoma of the salivary gland. American Journal of Clinical Pathology 88: 239–234.CrossRefGoogle ScholarPubMed
Nagao, K., Matsuzaki, O., Saiga, H., Sugano, I., Shigematsu, H., Kaneko, T., Katoh, T., Kitamura, T. (1981) Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland. Cancer 48: 113–121.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Quirke, P. (1990) Flow cytometry in the quantitation of DNA aneuploidy and cell proliferation in human disease. In Pathology of the Nucleus. (Underwood, J. C. E., ed.), Springer-Verlag. Berlin, pp 216–256.Google Scholar
Rivieré, A., Becker, J., Loning, T. (1991) Comparative investigation of c-erbB-2/neu expression in head and neck tumours and mammary cancer. Cancer 67: 2142–2149.3.0.CO;2-8>CrossRefGoogle Scholar
Sciubba, J. J., Batsakis, J. G. (1990) The major salivary glands. In Principles and Practice of Surgical Pathology. 2nd Edition. (Silverberg, S. G., ed.). Churchill-Livingstone, New York, pp 895–933.Google Scholar
Simpson, R. H. W., Sarsfield, P. T. L., Clarke, T., Babajews, A. V. (1990) Clear cell carcinoma of minor salivary glands. Histopathology 17: 433–438.CrossRefGoogle ScholarPubMed
Veloso, J. D., Solis, O. G., Barada, J. H., Fisher, H. A., Ross, J. S. (1992) DNA ploidy of oncocytic-granular renal cell carcinomas and renal oncocytomas by image analysis. Archives of Pathology and Laboratory Medicine 116: 154–158.Google ScholarPubMed