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Cisplatin-albumin complex for treatment of cancer of the head and neck

Published online by Cambridge University Press:  29 June 2007

G. C. M. Vreeburg ,
P. M. Stell ,
J. D. Holding  and
W. E. Lindup
G. C. M. Vreeburg
Affiliation:
Departments of Otorhinolaryngology, University of Liverpool.
P. M. Stell
Affiliation:
Departments of Otorhinolaryngology, University of Liverpool.
J. D. Holding
Affiliation:
Departments of Pharmacology & Therapeutics, University of Liverpool.
W. E. Lindup*
Affiliation:
Departments of Pharmacology & Therapeutics, University of Liverpool.
*
Department of Pharmacology & Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX.
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Abstract

Many patients with cancer of the head and neck are unable to receive or continue treatment with cisplatin, which is nephrotoxic, because of poor renal function. We present here, however, the case of a patient who underwent conventional cisplatin therapy but who then had to be withdrawn from treatment because of renal toxicity despite having undergone partial remission. Treatment was then changed to cisplatin in the form of a cisplatin-albumin complex which is not nephrotoxic. The patient went on to a histologically confirmed complete response and we suggest that although the cisplatin-albumin complex may not be as effective as the conventional form of the drug it offers a possible form of treatment of patients with compromised renal function who could not otherwise be treated.

Keywords

Head and neck neoplasmsCisplatin, cisplatin albumin complex
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 9 , September 1992 , pp. 832 - 833
Copyright
Copyright © JLO (1984) Limited 1992

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