Skip to main content Accessibility help
×
Home

Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia – a case report

  • Elizabeth C. Adam (a1), Dietlind U. Schumacher (a2) and Udo Schumacher (a1)

Abstract

The ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced by Pseudomonas aeruginosa stopped the beating of the cilia as in the controls. This reaction could be blocked by the pre-incubation of the lectin with its inhibitor fucose. As in the control, the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of a Pseudomonas aeruginosa infection could be advantageous for cystic fibrosis patients.

Copyright

Corresponding author

Address for correspondence: E. C. Adam, Human Morphology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX. Fax: +44 (0)1703 594433 email: ECA@soton.ac.uk

References

Hide All
Adam, E. C., Mitchell, B. S., Schumacher, D. U., Grant, G., Schumacher, U. (1997) Pseudomonas aeruginosa II lectin stops human ciliary beating: therapeutic implications of fucose. American Journal of Respiratory and Critical Care Medicine 155: 21022104.
De Bentzmann, S., Roger, P., Puchelle, E. (1996) Pseudomonas aeruginosa adherence to remodelling respiratory epithelium. European Respiratory Journal 9: 21452150.
Fick, R. B., Baltimore, R. S., Squier, S. V., Reynolds, S. Y. (1985) IgG proteolytic activity of Pseudomonas aeruginosa in cystic fibrosis. Journal of Infectious Diseases 151: 589598.
Hingley, S. T., Hastie, A. T., Kueppers, F., Higgins, M. L., Weinbaum, G., Shryock, T. (1986) Effect of ciliostatic factors from Pseudomonas aeruginosa on rabbit respiratory cilia. Infection and Immunity 51: 254262.
Ko, Y. H., Delannoy, M., Pederson, P. L. (1997) Cystic fibrosis, lung infections, and a human tracheal antimicrobial peptide (hTAP). FEBS Letters 405: 200208.
Warner, J. O. (1992) Immunology of cystic fibrosis. British Medical Bulletin 48: 893911.

Keywords

Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia – a case report

  • Elizabeth C. Adam (a1), Dietlind U. Schumacher (a2) and Udo Schumacher (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed