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Carcinoma cuniculatum of the larynx: a rare clinicopathological entity

  • R Puxeddu (a1), D Cocco (a2), G Parodo (a3), G Mallarini (a4), M Medda (a2) and P A Brennan (a5)...

Abstract

Objective:

Carcinoma cuniculatum is a rare variant of low-grade squamous cell carcinoma. We report the second case of carcinoma cuniculatum of the larynx in the literature.

Method:

Case report and review of the world literature concerning carcinoma cuniculatum of the larynx and upper aerodigestive tract.

Results:

A histologically proven carcinoma cuniculatum of the larynx is reported in a 72-year-old man. The patient underwent a supracricoid laryngectomy with crico-hyoidopexy, and was free of disease at 70 months after surgery. We emphasise the clinical presentation, histology and therapeutic approach of this rare tumour.

Conclusion:

To our knowledge this is the second report in the world literature of carcinoma cuniculatum of the larynx. Carcinoma cuniculatum of the larynx must be considered as a distinct ‘clinicopathological entity’ and close cooperation between the clinician and the pathologist is essential for the correct diagnosis of these tumour as regards to the correct classification and therapy.

Copyright

Corresponding author

Address for correspondence: Mr Roberto Puxeddu, Department of Otorhinolaryngology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK. E-mail: roberto.puxeddu@porthosp.nhs.uk

References

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1 Aird, I, Johnson, HD, Lennox, B, Stansfeld, AG. Epithelioma cuniculatum: a variety of squamous carcinoma peculiar to the foot. Br J Surg 1954;42:245–50
2 Kao, GF, Graham, JH, Helwig, EB. Carcinoma cuniculatum (verrucous carcinoma of the skin). A clinicopathologic study of 46 cases with ultrastructural observations. Cancer 1982;49:2395–403
3 Bendelac, A, Grossin, M, Sigal, M, Crickx, B, Godeau, MJ, Bocquet, L et al. Epithelioma cuniculatum. Apropos of a case with review of the literature. Ann Pathol 1984;4:223–9
4 Schwartz, RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995;32:121
5 Ho, J, Diven, DG, Butler, PJ, Tyring, SK. An ulcerating verrucous plaque on the foot. Verrucous carcinoma (epithelioma cuniculatum). Arch Dermatol 2000;136:547–8, 500–1
6 Coldiron, BM, Brown, FC, Freeman, RG. Epithelioma cuniculatum (carcinoma cuniculatum) of the thumb: a case report and literature review. J Dermatol Surg Oncol 1986;12:1150–5
7 Flieger, S, Owinski, T. Epithelioma cuniculatum an unusual form of mouth and jaw neoplasm [in Polish]. Czas Stomatol 1977;30:395401
8 Kahn, JL, Blez, P, Gasser, B, Weill-Bousson, M, Vetter, JM, Champy, M. Carcinoma cuniculatum. Apropos of 4 cases with orofacial involvement. Rev Stomatol Chir Maxillofac 1991;92:2733
9 Delahaye, JF, Janser, JC, Rodier, JF, Auge, B. Cuniculatum carcinoma. 6 cases and review of the literature [in French]. J Chir (Paris) 1994;131:73–8
10 Huault, M, Laroche, C, Levy, J, Laxenaire, A, Roucayrol, AM, Scheffer, P. Epithelioma cuniculatum. Apropos of a case in the anterior gingiva with involvement of the mandibular symphyseal bone and reconstruction using a fibular osteocutaneous flap and integrated implants. Rev Stomatol Chir Maxillofac 1998;99:143–8
11 Allon, D, Kaplan, I, Manor, R, Calderon, S. Carcinoma cuniculatum of the jaw: a rare variant of oral carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:601–8
12 Gassler, N, Helmke, B, Schweigert, HG, Hassfeld, S, Otto, HF, Flechtenmacher, C. Carcinoma cuniculatum of the oral cavity. A contribution to the differential diagnosis of potentially malignant papillary lesions of mouth mucosa [in German]. Pathologe 2002;23:313–17
13 De Petris, G, Lewin, M, Shoji, T. Carcinoma cuniculatum of the esophagus. Ann Diagn Pathol 2005;9:134–8
14 Van Geertruyden, JP, Olemans, C, Laporte, M, Noel, JC. Verrucous carcinoma of the nail bed. Foot Ankle Int 1998;19:327–8
15 Kraus, FT, Perezmesa, C. Verrucous carcinoma: clinical and pathological study of 105 cases involving oral cavity, larynx and genitalia. Cancer 1966;19:2638
16 Eisenberg, E, Rosenberg, B, Krutchkoff, DJ. Verrucous carcinoma: a possible viral pathogenesis. Oral Surg Oral Med Oral Pathol 1985;59:52–7
17 Noel, JC, Peny, MO, Goldschmidt, D, Verhest, A, Heenen, M, De Dobbeleer, G. Human papillomavirus type 1 DNA in verrucous carcinoma of the leg. J Am Acad Dermatol 1993;29:1036–8
18 Petersen, CS, Sjolin, KE, Rosman, N, Lindeberg, H. Lack of human papillomavirus DNA in carcinoma cuniculatum. Acta Derm Venereol 1994;74:231–2
19 Martin, F, Dalac, S, Lambert, D. Verrucous carcinoma. Nosologic aspects, apropos of 4 cases. Ann Dermatol Venereol 1995;122:399403
20 Zielonka, E, Goldschmidt, D, de Fontaine, S. Verrucous carcinoma or epithelioma cuniculatum plantare. Eur J Surg Oncol 1997;23:86–7
21 Lever, WF, Schaumberg-Lever, G. Histopathology of the Skin, 7th edn. Philadelphia: JB Lippincott, 1990;558–9
22 Shanmugaratnam, K, Sobin, LK. The World Health Organization Histological Classification of Tumours of the Upper Respiratory Tract and Ear, 2nd edn. Berlin: Springer-Verlag, 1991
23 McKee, PH, Wilkinson, JD, Corbett, MF, Davey, A, Sauven, P, Black, MM. Carcinoma cuniculatum: a cast metastasizing to skin and lymph nodes. Clin Exp Dermatol 1981;6:613–18

Keywords

Carcinoma cuniculatum of the larynx: a rare clinicopathological entity

  • R Puxeddu (a1), D Cocco (a2), G Parodo (a3), G Mallarini (a4), M Medda (a2) and P A Brennan (a5)...

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