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Benefits of pre-labyrinthectomy intratympanic gentamicin: contralateral vestibular responses

  • N Amiraraghi (a1), M Gaggini (a1), J A Crowther (a1), R Locke (a1), W Taylor (a2) and G Kontorinis (a1)...



To determine the impact of pre-operative intratympanic gentamicin injection on the recovery of patients undergoing translabyrinthine resection of vestibular schwannomas.


This prospective, case–control pilot study included eight patients undergoing surgical labyrinthectomy, divided into two groups: four patients who received pre-operative intratympanic gentamicin and four patients who did not. The post-operative six-canal video head impulse test responses and length of in-patient stay were assessed.


The average length of stay was shorter for patients who received intratympanic gentamicin (6.75 days; range, 6–7 days) than for those who did not (9.5 days; range, 8–11 days) (p = 0.0073). Additionally, the gentamicin group had normal post-operative video head impulse test responses in the contralateral ear, while the non-gentamicin group did not.


Pre-operative intratympanic gentamicin improves the recovery following vestibular schwannoma resection, eliminating, as per the video head impulse test, the impact of labyrinthectomy on the contralateral labyrinth.


Corresponding author

Author for correspondence: Mr Georgios Kontorinis, Department of Otolaryngology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK E-mail: Fax: +44 1413 478 028


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Mr G Kontorinis takes responsibility for the integrity of the content of the paper

Presented orally at the Annual Meeting of the North American Skull Base Society, 16–18 February 2018, San Diego, California, USA.



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