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Autologous fat injection therapy including a high concentration of adipose-derived regenerative cells in a vocal fold paralysis model: animal pilot study

  • N Nishio (a1), Y Fujimoto (a1), K Suga (a1), Y Iwata (a2), K Toriyama (a3), K Takanari (a3), Y Kamei (a3), T Yamamoto (a4) and M Gotoh (a4)...

Abstract

Objectives:

To verify the effectiveness and safety of the addition of adipose-derived regenerative cells to autologous fat injection therapy.

Methods:

Unilateral vocal fold paralysis models were made by cutting the right recurrent laryngeal nerve in two pigs. At day 30, 0.5 ml adipose-derived regenerative cells mixed with 1 ml autologous fat was injected into the right vocal fold of one pig, with the other receiving 0.5 ml Ringer's solution mixed with 1 ml autologous fat. At day 120, fibrescopy, laser Doppler flowmeter, computed tomography, vocal function evaluation and histological assessment were conducted.

Results:

Although histological assessment revealed atrophy of the thyroarytenoid muscle fibre in both pigs, there was remarkable hypertrophy of the thyroarytenoid muscle fibre in the area surrounding the adipose-derived regenerative cells injection site.

Conclusion:

The addition of a high concentration of adipose-derived regenerative cells to autologous fat injection therapy has the potential to improve the treatment outcome for unilateral vocal fold paralysis.

Copyright

Corresponding author

Address for correspondence: Dr Naoki Nishio, Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466–8550, Japan Fax: +11 81 52 744 2325 E-mail: naokin@med.nagoya-u.ac.jp

References

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Keywords

Autologous fat injection therapy including a high concentration of adipose-derived regenerative cells in a vocal fold paralysis model: animal pilot study

  • N Nishio (a1), Y Fujimoto (a1), K Suga (a1), Y Iwata (a2), K Toriyama (a3), K Takanari (a3), Y Kamei (a3), T Yamamoto (a4) and M Gotoh (a4)...

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