Hostname: page-component-77c89778f8-gvh9x Total loading time: 0 Render date: 2024-07-22T22:40:26.352Z Has data issue: false hasContentIssue false
  • English
  • Français

Audiovestibular manifestations of the antiphospholipid syndrome

Published online by Cambridge University Press:  29 June 2007

Tim Vyse ,
Linda M. Luxon  and
Mark J. Walport
Tim Vyse
Affiliation:
Rheumatology Unit, Department of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN.
Linda M. Luxon*
Affiliation:
Department of Neuro-otology, The National Hospital, Queen Square, London WC1N 3BG
Mark J. Walport
Affiliation:
Rheumatology Unit, Department of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN.
*
Professor Linda M. Luxon, B.Sc, F.R.C.P., Institute of Laryngology and Otology, Division of Audiological Medicine, 330/332 Gray's Inn Road, London WC1X8EE.
Get access Rights & Permissions [Opens in a new window]

Abstract

We report on two patients who have high titres of antiphospholipid antibodies, both of whom had acute audiovestibular failure. One of the patients had systemic lupus erythematosus. The other patient had primary antiphospholipid syndrome: audiovestibular symptoms have not been reported in this condition. The occurrence of acute audiovestibular failure in the primary antiphospholipid syndrome raises the question as to whether patients presenting with acute deafness or vestibular disturbance should be screened for the presence of anticardiolipin antibodies.

Keywords

Lupus erythematosussystemicAntibodies, antiphospholipidAcute audiovestibular failure
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 1 , January 1994 , pp. 57 - 59
Copyright
Copyright © JLO (1984) Limited 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alving, B. M.Baldwin, D. E., Richards, R. L., Jackson, B. L. (1985) The dilute phospholipid activated partial thromboplastin time: a sensitive assay for the verification of lupus anticoagulant. Thrombosis Haemostasis 54: 709–712.Google Scholar
Asherson, R. A., Mercey, D., Phillips, G., Sheehan, N., Gharavi, A. E., Harris, E. N., Hughes, G. R. V. (1987) Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Annals of Rheumatic Diseases 46: 605–611.CrossRefGoogle ScholarPubMed
Asherson, R. A., Merry, R.Acheson, J. E., Harris, E. N., Hughes, G. R. V. (1989) Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the primary antiphospholipid syndrome. Annals of Rheumatic Diseases 48: 358–361.CrossRefGoogle ScholarPubMed
Barber, H. O., Dionne, J. (1971) Vestibular findings in vertebrobasilar ischaemia. Annals of Otology 80: 805–812.Google Scholar
Barna, B. R.Hughes, G. B. (1988) Autoimmunity and otologic disease: clinical and experimental aspects. Clinical and Laboratory Medicine 8: 385–398.CrossRefGoogle ScholarPubMed
Bouchez, B., Arnott, G., Hatron, R Y. (1985) Chorea and systemic lupus erythematosus with circulating lupus anticoagulant. Three cases. Reviews in Neurology (Paris) 14: 571–577.Google Scholar
Calderelli, D. D., Rejowslei, J. E., Corey, J. P. (1984) Sensorineuronal hearing loss in lupus erythematosus. American Journal of Otology 7: 210–213.Google Scholar
Clauvel, J. P., Tchobroutsky, C, Danon, E.Sultan, Y.Intrator, L., Brouet, J. C. (1986) Spontaneous recurrent fetal wastage and auto-immune abnormalities: a study of 14 cases. Clinical Immunology and Immunopathology 39: 523–530.CrossRefGoogle Scholar
Cluxton, H. E., Krause, L. A. M., Smith, W. L. (1943) Acute lupus erythematosus disseminata. Annals of Internal Medicine 19: 843–847.Google Scholar
Elias, M., Eldor, A. (1984) Thromboembolism in patients with the ‘lupus’-like circulating anticoagulant. Archives of Internal Medicine 144: 519–525.CrossRefGoogle Scholar
Feinglass, E. J., Arnett, F. C.Dorsch, C. A., Zizic, T. M., Stevens, M. B. (1976) Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 55: 323–339.CrossRefGoogle ScholarPubMed
Francis, D. A., Bronstein, A. M., Rudge, P., du Bonlay, E. P. G. H. (1992) The site of brain stem lesions causing semicircular canal paresis: an MRI study. Journal of Neurology, Neurosurgery and Psychiatry 55: 446–449.CrossRefGoogle ScholarPubMed
Gussen, R. (1976) Sudden deafness of vascular origin. A human temporal bone study. Annals of Otology, Rhinology and Laryngology 85: 94–100.CrossRefGoogle ScholarPubMed
Harris, E. N., Gharavi, A. E., Boey, M. L., Patel, B. M., Mackworth-Young, C. G., Loizou, S., Hughes, G. R. V. (1983) Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 11: 1211–1214.CrossRefGoogle Scholar
Harris, E. N., Gharavi, A. E., Asherson, R. A., Boey, M. L., Hughes, G. R. V. (1984) Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clinical and Experimental Rheumatology 2: 47–51.Google ScholarPubMed
Harris, E. N., Gharavi, A. E., Hughes, G. R. V. (1985) Anti-phospholipid antibodies. Clinics in Rheumatic Diseases 11: 591–609.CrossRefGoogle ScholarPubMed
Harris, E. N., Chan, J. K. H., Asherson, R. A., Aber, V. R., Gharavi, A. E., Hughes, G. R. V. (1986)Google Scholar
Hart, R. G., Miller, V. T.Coull, B. M., Bril, V. E. (1984) Cerebral infarction associated with lupus anticoagulant: preliminary report. Stroke 15: 114–118.CrossRefGoogle ScholarPubMed
Johnson, R. T.Richardson, E. P. (1968) The neurological manifestations of systemic lupus erythematosus: a clinico-pathological study of 24 cases and review of the literature. Medicine (Baltimore) 47: 337–369.CrossRefGoogle Scholar
Kimura, M., Perlman, H. B. (1958) Arterial obstruction of the labyrinth. (I) Cochlear changes. (II) Vestibular changes. Annals of Otology, Rhinology and Laryngology 67: 347–365.CrossRefGoogle Scholar
Lechner, K., Pabinger-Fashing, I. (1985) Lupus anticoagulants and thrombosis. Haemostasis 15: 254–262.Google ScholarPubMed
Loizou, S., McCrea, J. D., Rudge, A. C.Reynolds, R., Boyle, C. C.Harris, E. N. (1985) Measurement of anticardiolipin antibody by an enzyme-linked immunosorbent assay (ELISA): standardization and quantification of results. Clinical and Experimental Immunology 62: 738–745.Google Scholar
Mackworth-Young, C. G., Loizou, S., Walport, M. J. (1989) Primary antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorder. Annals of Rheumatic Diseases 48: 362–376.CrossRefGoogle ScholarPubMed
Row-Jones, J. M., Macallan, D. C.Sorooshian, M. (1990) Polyarteritis nodosa presenting as bilateral sudden onset of cochleovestibular failure in a young woman. Journal of Laryngology and Otology 104: 562–564.CrossRefGoogle Scholar
Trumer, D. R., Craven, J. P., Morten, J. I., Mitchel, C. (1989) Autoimmune disease and cochlear pathology in the C3H/lpr strain mouse. Hearing Research. 89: 57–66.Google Scholar
Yoon, T. H., Paparella, M. M., Schachern, P. A. (1989) Systemic vasculitis: a temporal bone histopathologic study. Laryngoscope 99: 600–609.CrossRefGoogle ScholarPubMed