Skip to main content Accessibility help

An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma

  • U Aydil (a1), M Akmansu (a2), Y Kizil (a1), Ö Yazici (a2), S Üstün (a1), F Karaloğlu (a1) and A Köybaşioğlu (a1)...



To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma.


A retrospective outcome analysis study was performed using data from a tertiary referral centre.


Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (p = 0.502). There was no significant association between laryngeal preservation rates and age (p = 0.779), anterior commissure involvement (p = 0.081), tumour stage (1a or 1b) (p = 0.266) or treatment modality (surgery or radiotherapy; p = 0.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy vs 10.0 per cent for surgery; p = 0.220). The overall 5-year regional recurrence rate was 1.2 per cent.


Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes.


Corresponding author

Address for correspondence: Dr Utku Aydil, Gazi Ün Tıp Fak KBB AD, 06500 Beşevler, Ankara, Turkey Fax: +90 312 202 4357 E-mail:


Hide All
1Spector, JG, Sessions, DG, Chao, KSC, Haughey, BH, Hanson, JM, Simpson, JR et al. Stage I (T1N0M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice presentation. Head Neck 1999;21:707–17
2Nomiya, T, Nemoto, K, Wada, H, Takai, Y, Yamada, S. Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope 2008;118:1417–21
3Sjögren, EV, van Rossum, MA, Langeveld, TP, Voerman, MS, van de Kamp, VA, Friebel, MO. Voice outcome in T1a midcord glottic carcinoma: laser surgery vs radiotherapy. Arch Otolaryngol Head Neck Surg 2008;134:965–72
4Cellai, E, Frata, P, Magrini, SM, Paiar, F, Barca, R, Fondelli, S et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys 2005;63:1378–86
5Steiner, W, Ambrosch, P, Rödel, RMW, Kron, M. Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 2004;114:1485–91
6Franchin, G, Minatel, E, Gobitti, C, Talamini, R, Vaccher, E, Sartor, G et al. Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients. Cancer 2003;98:765–72
7Karatzanis, AD, Psychogios, G, Zenk, J, Waldfahrer, F, Hornung, J, Velegrakis, GA et al. Comparison among different available surgical approaches in T1 glottic cancer. Laryngoscope 2009;119:1704–8
8Peeters, AJ, van Gogh, CD, Goor, KM, Verdonck de Leeuw, IM, Langendijk, JA, Mahieu, HF. Health status and voice outcome after treatment for T1a glottic carcinoma. Eur Arch Otorhinolaryngol 2004;261:534–40
9Anonymous. Larynx. In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn.New York: Springer, 2010;5767
10Kasapoglu, F, Erisen, L, Coskun, H, Basut, O. Endolaryngeal cordectomy using cold instruments for treatment of T1 glottic cancers. Eur Arch Otorhinolaryngol 2007;264:1065–70
11Goor, KM, Peeters, AJ, Mahieu, HF, Langendijk, JA, Leemans, CR, Verdonck-de Leeuw, IM et al. Cordectomy by CO2 laser or radiotherapy for small T1a glottic carcinomas: costs, local control, survival, quality of life, and voice quality. Head Neck 2007;29:128–36
12Schrijvers, ML, van Riel, EL, Langendijk, JA, Dikkers, FG, Schuuring, E, van der Wal, JE et al. Higher laryngeal preservation rate after CO2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma. Head Neck 2009;31:759–64
13Chone, CT, Yonehara, E, Martins, JEF, Altemani, A, Crespo, AN. Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Arch Otolaryngol Head Neck Surg 2007;133:882–7
14Sachse, F, Stoll, W, Rudack, C. Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck 2009;31:531–7
15Rödel, RM, Steiner, W, Müller, RM, Kron, M, Matthias, C. Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck 2009;31:583–92
16Anonymous. General information on cancer staging and end-results reporting (part I). In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn.New York: Springer, 2010;314
17Connor, S. Laryngeal cancer: how does the radiologist help? Cancer Imaging 2007;7:93103
18Gowda, RV, Henk, JM, Mais, KL, Sykes, AJ, Swindell, R, Slevin, NJ. Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience. Radiother Oncol 2003;68:105–11
19Holsinger, FC, Funk, E, Roberts, DB, Diaz, EM Jr.Conservation laryngeal surgery versus total laryngectomy for radiation failure in laryngeal cancer. Head Neck 2006;28:779–84
20Ganly, I, Patel, SG, Matsuo, J, Singh, B, Kraus, DH, Boyle, JO et al. Results of surgical salvage after failure of definitive radiation therapy for early-stage squamous cell carcinoma of the glottic larynx. Arch Otolaryngol Head Neck Surg 2006;132:5966
21McLaughlin, MP, Parsons, JT, Fein, DA, Stringer, SP, Cassisi, NJ, Mendenhall, WM et al. Salvage surgery after radiotherapy failure in T1-T2 squamous cell carcinoma of the glottic larynx. Head Neck 1996;18:229–35
22Sjögren, EV, Langeveld, TPM, Baatenburg de Jong, RJ. Clinical outcome of T1 glottic carcinoma since the introduction of endoscopic CO2 laser surgery as treatment option. Head Neck 2008;30:1167–74


An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma

  • U Aydil (a1), M Akmansu (a2), Y Kizil (a1), Ö Yazici (a2), S Üstün (a1), F Karaloğlu (a1) and A Köybaşioğlu (a1)...


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed