Skip to main content Accessibility help
×
Home

Aggressive cutaneous squamous cell carcinoma of the head and neck in patients with chronic lymphocytic leukaemia

  • B. E. J. Hartley (a1), A. E. Searle (a1), N. M. Breach (a1), P. H. Rhys-Evans (a1) and J. M. Henk (a1)...

Abstract

We describe multiple cutaneous squamous cell carcinomas of the head and neck in five patients with chronic lymphocytic leukaemia (CLL). When associated with CLL, cutaneous squamous cell carcinomata behave in a much more aggressive manner than otherwise expected. Four patients developed local recurrence after primary treatment. All five patients developed lymph node metastases containing squamous cell carcinoma. Three of five patients (60 per cent) had multiple primary lesions.

Whereas the increased incidence of second cancers in CLL and notably of skin cancers is documented, little has been written to describe the aggressive behaviour of these tumours. It is important, when treating these patients, to be aware of the high tendency towards local recurrence and lymph node metastasis and to consider an aggressive management plan and careful follow-up.

Copyright

Corresponding author

Address for correspondence: Mr B. E. J. Hartley, B.Sc. F.R.C.S., ENT Registrar, The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.

References

Hide All
Beresford, O. D. (1952) Chronic lymphatic leukaemia associated with malignant disease. British Journal of Cancer 6: 339344.
Berg, J. W. (1967) The incidence of multiple primary cancers. l. Development of further cancers in patients with lymphomas, leukaemias and myeloma. Journal of the National Cancer Institute 38: 748752.
Frierson, H. F., Deutsch, B. D., Levine, P. A. (1988) Clinicopathologic features of squamous cell carcinomas of the head and neck in patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma. Human Pathology 19(12): 13971402.
Gunz, F. W., Angus, H. B. (1965) Leukaemia and cancer in the same patient. Cancer 18: 145152.
Katz, A. D., Urbach, F., Licienfield, A. M. (1957) The frequency and risk of metastasis in squamous cell carcinoma of the skin. Cancer 10: 11621166.
Manusow, D., Wienerman, B. H. (1975) Subsequent neoplasia in chronic lymphocytic leukaemia. Journal of the American Medical Association 232: 267269.
Perez-Reyes, N., Farhi, D. C. (1987) Squamous cell carcinoma of the head and neck in patients with well-differentiated lymphocytic lymphoma. Cancer 59: 540544.
Villet, W. T., Staples, W. G., Getaz, E. P. (1977) Squamous carcinoma metastasis to lymph nodes in patients with well differentiated lymphocytic lymphoma. South African Medical Journal 51: 738.
Weimar, V. M., Ceilley, R. I., Goeken, J. A. (1979) Aggressive biologic behavior of basal- and squamous-cell cancers in patients with chronic lymphocytic leukaemia or chronic lymphocytic lymphoma. Journal of Dermatological Surgical Oncology 5: 609614.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed