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Primary non-Hodgkin’s lymphoma of the larynx (Stage IE) diagnosed by gene rearrangement

Published online by Cambridge University Press:  08 March 2006

Nobuo Ohta ,
Hachiro Suzuki ,
Shigeru Fukase ,
Naoko Ksajima  and
Masaru Aoyagi
Nobuo Ohta
Affiliation:
Department of Otolaryngology, Yamagata University School of Medicine, Japan
Hachiro Suzuki
Affiliation:
Department of Otolaryngology, Yamagata Prefectural Central Hospital, Japan
Shigeru Fukase
Affiliation:
Department of Otolaryngology, Yamagata Prefectural Central Hospital, Japan
Naoko Ksajima
Affiliation:
Department of Otolaryngology, Yamagata University School of Medicine, Japan
Masaru Aoyagi
Affiliation:
Department of Otolaryngology, Yamagata University School of Medicine, Japan
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Abstract

An extremely rare case of primary non-Hodgkin’s lymphoma of the larynx (Stage IE) diagnosed by gene rearrangement is reported. The patient was a 76-year-old man with a chief complaint of pharyngeal discomfort. Remission was obtained by excision of the tumour and radiotherapy. Surface phenotypic studies of the laryngeal lesion demonstrated a main population of B-cells expressing L-26, some of the atypical lymphocytes positive with UCHL-1. Genotypic analysis of the specimen disclosed a clonal rearrangement of the immunoglobulin heavy chain with the same rearrangement pattern. These data indicate that this patient had non-Hodgkin’s lymphoma with diffuse large B-cell type. Gene rearrangement analysis was useful for diagnosis. Diagnostic and therapeutic options are discussed in light of the current literature.

Keywords

LymphomaNon Hodgkin’sLarynxDiagnostic Techniques and Procedures
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 7 , July 2001 , pp. 596 - 599
Copyright
© Royal Society of Medicine Press Limited 2001

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