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Adjuvant chemotherapy in stage III and IV squamous cell carcinoma of the head and neck

Published online by Cambridge University Press:  29 June 2007

A. Klima ,
TH Klippstein ,
L. Bergmann ,
S. Szepesi  and
C. V. Ilberg
A. Klima*
Affiliation:
Frankfurt/Main, West Germany
TH Klippstein
Affiliation:
Frankfurt/Main, West Germany
L. Bergmann
Affiliation:
Frankfurt/Main, West Germany
S. Szepesi
Affiliation:
Frankfurt/Main, West Germany
C. V. Ilberg
Affiliation:
Frankfurt/Main, West Germany
*
Dr. A. Klima, M.D. HNO-Universitätsklinik, Th. Stern Kai 7, 6000 Frankfurt/Main, West Germany.
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Abstract

Summary Initial combination drug regimen containing cisplatin in patients with stage III and IV head and neck cancer produced a high percentage of clinical response. This trial was initiated to assess the role of multimodality treatment (chemotherapy plus radiotherapy) versus chemotherapy alone. Ninety-six patients entered into this study; 80 patients were evaluable at time of analysis (Table I). Patients were randomized between chemotherapy and radiotherapy (group I) and chemotherapy alone (group II). The chemotherapy administered consisted of cisplatin, bleomycin and methotrexate and was given in 2 cycles over 35 days. Local radiotherapy followed. In group II 3 cycles of chemotherapy were given without radiotherapy. The overall tumour response after chemotherapy rose up to 75 per cent. After radiotherapy in group II the response rate sank to 59 per cent. In both regimes the remission duration was very short. Patients receiving only two cycles of chemotherapy do not have a statistically shorter survival than patients, who were treated by chemotherapy plus radiotherapy, or by a 3rd cycle of chemotherapy.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 4 , April 1988 , pp. 337 - 340
Copyright
Copyright © JLO (1984) Limited 1988

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References

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