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Vaccination with hatched but non-activated, non-viable oncospheres of Taenia taeniaeformis in rats

Published online by Cambridge University Press:  05 June 2009

A. Ito  and
A. Hashimoto
A. Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu 500
A. Hashimoto
Affiliation:
Veterinary Hospital, Faculty of Agriculture, Gifu University, Gifu 501, Japan
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Abstract

The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a Taenia taeniaeformis/rat system, since preparation of these oncospheres in vitro is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.

Keywords

Taenia taeniaeformisvaccinationnon-viable oncospheresratCestoda
Type
Research Note
Information
Journal of Helminthology , Volume 67 , Issue 2 , June 1993 , pp. 165 - 168
Copyright
Copyright © Cambridge University Press 1993

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References

Dempster, R. P., Berridge, M. V., Harrison, G. B. L. & Heath, D. D. (1991) Echinococcus granulosus: development of an intermediate host mouse model for use in vaccination studies. International Journal for Parasitology, 21, 549–554.CrossRefGoogle ScholarPubMed
Ito, A. & Yamamoto, M. (1976) The mode of active protection against Hymenolepis nana reinfection in mice inoculated with different doses of shell-free eggs. Japanese Journal of Parasitology, 25, 247–253.Google Scholar
Ito, A., Bøgh, H. O., Lightowlers, M. W., Mitchell, G. F., Takami, T., Kamiya, M., Onitake, K. & Rickard, M. D. (1991) Vaccination against Taenia taeniaeformis infection in rats using a recombinant protein and preliminary analysis of the induced antibody response. Molecular and Biochemical Parasitology, 44, 43–52.CrossRefGoogle ScholarPubMed
Johnson, K. S., Harrison, G. B. L., Lightowlers, M. W., O'hoy, K. L., Cougle, W. G., Dempster, R. P., Lawrence, S. B., Vinton, J. G., Heath, D. D. & Rickard, M. D. (1989) High level protection against a helminth parasite induced by a defined recombinant antigen. Nature, 338, 585–587.CrossRefGoogle Scholar
Lightowlers, M. W., Mitchell, G. F., Bowtell, D. D. L., Anders, R. F. & Rickard, M. D. (1984) Immunization against Taenia taeniaeformis in mice: studies on the characterization of antigens from oncospheres. International Journal for Parasitology, 14, 321–333.CrossRefGoogle ScholarPubMed
Lightowlers, M. W., Mitchell, G. F. & Rickard, M. D. (1993) Cestodes. In: Immunology and Molecular Biology of Parasitic Infections (editor, Warren, K. S.) Blackwell, Oxford, 438–472.Google Scholar
Rajasekariah, G. R., Rickard, M. D. & Mitchell, G. F. (1980) Immunization of mice against infection with Taenia taeniaeformis using various antigens prepared from eggs, oncospheres, developing larvae and strobilocerci. International Journal for Parasitology, 10, 315–324.CrossRefGoogle ScholarPubMed