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Treatment of Nippostrongylus brasiliensis in normal and SPF rats using tetramisole loaded into zeolite

Published online by Cambridge University Press:  05 June 2009

S. K. Shaker ,
A. Dyer  and
D. M. Storey
S. K. Shaker
Affiliation:
Department of Biological Sciences, University of Salford, Salford, MS 4WT, UK
A. Dyer
Affiliation:
Department of Chemistry and Applied Chemistry, University of Salford, Salford, MS 4WT, UK
D. M. Storey
Affiliation:
Department of Biological Sciences, University of Salford, Salford, MS 4WT, UK
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Abstract

Administration to rats of tetramisole loaded into zeolite was more successful in killing adults of Nippostrongylus brasiliensis than the administration of tetramisole alone. The most successful treatment occurred in SPF (Specific Pathogen Free) rats dosed with tetramisole loaded into zeolite and no worms were present in this group at autopsy eight days post-infection. It is concluded that the slow release of drug from the zeolite matrix improved its efficacy, especially in removing worms from low-grade infections.

Keywords

Nippostrongylus brasiliensisratNematodatetramisolechemotherapyanthelminticsslow-release
Type
Research Article
Information
Journal of Helminthology , Volume 66 , Issue 4 , December 1992 , pp. 288 - 292
Copyright
Copyright © Cambridge University Press 1992

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References

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