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Studies with Brugia pahangi 12. The activity of levamisole

Published online by Cambridge University Press:  05 June 2009

Rosemary Rogers  and
D. A. Denham
Rosemary Rogers
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicin, Keppel Street, London WC1E 7HT
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicin, Keppel Street, London WC1E 7HT
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Abstract

The effects of levamisole on adults, third stage infective larvae, and microfilariae of Brugia pahangi were studied in in vitro culture and in vivo against developing stages in the vector mosquito and in infected cats. In vitro the drug was effective only at dose levels much higher than can be tolerated by mammals. It was active against the developmental stages of the worm in the vector Aedes aegypti.

The drug was strongly microfilaricidal in cats but less effective against adult worms.

Type
Research Article
Information
Journal of Helminthology , Volume 50 , Issue 1 , March 1976 , pp. 21 - 28
Copyright
Copyright © Cambridge University Press 1976

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References

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