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Prevalence of cystic echinococcosis in Iran: a systematic review and meta-analysis

  • H.R. Khalkhali (a1), M. Foroutan (a2) (a3), S. Khademvatan (a4), H. Majidiani (a2) (a3), S. Aryamand (a3), P. Khezri (a3) and A. Aminpour (a4)...

Abstract

As a significant zoonosis, cystic echinococcosis (CE) is endemic in some parts of the world, such as the Middle East. There are studies on the prevalence of this infection in animal and human reservoirs in Iran; hence, we conducted this meta-analysis to elucidate the prevalence of CE in Iran. English (PubMed, Scopus, Web of Science, Science Direct and Google Scholar) and Persian (Magiran, Iran Medex, Iran Doc and SID) databases were explored. In the case of definitive, animal and human intermediate hosts, 37, 90 and 33 studies, respectively, have been included in the current review from January 1990 to December 2015. According to outcomes of the heterogeneity test, either Der Simonian and Laird's random-effects method or Mantel–Haenszel's fixed-effects method were employed to pool the estimations. The pooled prevalence of Echinococcus granulosus infection in definitive hosts was calculated as 23.6% (95% confidence interval (CI) = 17.6–30.1%). The weighted prevalence of animal and human hydatidosis was calculated as 15.6% (95% CI = 14.2–17.1%) and 4.2% (95% CI = 3.0–5.5%), respectively. Meanwhile, most cases of human hydatidosis were in southern Iran, with a prevalence of 5.8% (3.2–9.2%). In terms of human hydatidosis, more infections were found in rural regions, and mostly in female individuals. Egger's regression test revealed publication bias, with a remarkable impact on total prevalence of the infection in animal intermediate hosts (P < 0.001), while it was not significant in human hosts (P = 0.4) and definitive hosts (P = 0.3). According to the weighted estimated prevalence of cystic echinococcosis and its financial burden, implementing appropriate control programmes should be compulsory to decrease the burden of the disease in Iran.

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Corresponding author

*Fax: (+98 44) 3332036 E-mail: khademvatan@yahoo.com and hamidreza.majidiani@gmail.com

References

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Al-Qaoud, K.M., Abdel-Hafez, S.K. & Craig, P.S. (2003) Canine echinococcosis in northern Jordan: increased prevalence and dominance of sheep/dog strain. Parasitology Research 90, 187191.
Bardonnet, K., Piarroux, R., Dia, L., Schneegans, F., Beurdeley, A., Godot, V. & Vuitton, D.A. (2002) Combined eco-epidemiological and molecular biology approaches to assess Echinococcus granulosus transmission to humans in Mauritania: occurrence of the ‘camel’ strain and human cystic echinococcosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 383386.
Barnes, T.S., Deplazes, P., Gottstein, B., Jenkins, D.J., Mathis, A., Siles-Lucas, M., Torgerson, P.R., Ziadinov, I. & Heath, D.D. (2012) Challenges for diagnosis and control of cystic hydatid disease. Acta Tropica 123, 17.
Budke, C.M., Carabin, H., Ndimubanzi, P.C., Nguyen, H., Rainwater, E., Dickey, M., Bhattarai, R., Zeziulin, O. & Qian, M.B. (2013) A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. American Journal of Tropical Medicine and Hygiene 88, 10111027.
Cardona, G.A. & Carmena, D. (2013) A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. Veterinary Parasitology 192, 1032.
Carmena, D. & Cardona, G.A. (2013) Canine echinococcosis: global epidemiology and genotypic diversity. Acta Tropica 128, 441460.
Carmena, D. & Cardona, G.A. (2014) Echinococcosis in wild carnivorous species: epidemiology, genotypic diversity, and implications for veterinary public health. Veterinary Parasitology 202, 6994.
Craig, P.S., Rogan, M.T. & Campos-Ponce, M. (2003) Echinococcosis: disease, detection and transmission. Parasitology 127 (Suppl.), S520.
Dakkak, A. (2010) Echinococcosis/hydatidosis: a severe threat in Mediterranean countries. Veterinary Parasitology 174, 211.
Deplazes, P., Gottstein, B., Eckert, J., Jenkins, D.J., Ewald, D. & Jimenez-Palacios, S. (1992) Detection of Echinococcus coproantigens by enzyme-linked immunosorbent assay in dogs, dingoes and foxes. Parasitology Research 78, 303308.
Duscher, G., Prosl, H. & Joachim, A. (2005) Scraping or shaking – a comparison of methods for the quantitative determination of Echinococcus multilocularis in fox intestines. Parasitology Research 95, 4042.
Eckert, J. (2003) Predictive values and quality control of techniques for the diagnosis of Echinococcus multilocularis in definitive hosts. Acta Tropica 85, 157163.
Eckert, J. & Deplazes, P. (2004) Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clinical Microbiology Reviews 17, 107135.
European Food Safety Authority (2015) The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2013. EFSa Journal 13, 3991 pp.
Fasihi Harandi, M., Budke, C.M. & Rostami, S. (2012) The monetary burden of cystic echinococcosis in Iran. PLoS Neglected Tropical Diseases 6, e1915.
Foroutan, M., Khademvatan, S., Majidiani, H., Khalkhali, H., Hedayati-Rad, F., Khashaveh, S. & Mohammadzadeh, H. (2017) Prevalence of Leishmania species in rodents: a systematic review and meta-analysis in Iran. Acta Tropica 172, 164172.
Foroutan-Rad, M., Khademvatan, S., Majidiani, H., Aryamand, S., Rahim, F. & Malehi, A.S. (2016a) Seroprevalence of Toxoplasma gondii in the Iranian pregnant women: a systematic review and meta-analysis. Acta Tropica 158, 160169.
Foroutan-Rad, M., Majidiani, H., Dalvand, S., Daryani, A., Kooti, W., Saki, J., Hedayati-Rad, F. & Ahmadpour, E. (2016b) Toxoplasmosis in blood donors: a systematic review and meta-analysis. Transfusion Medicine Reviews 30, 116122.
Guo, Z.H., Kubo, M., Kudo, M., Nibe, K., Horii, Y. & Nonaka, N. (2011) Growth and genotypes of Echinococcus granulosus found in cattle imported from Australia and fattened in Japan. Parasitology International 60, 498502.
Inangolet, F.O., Biffa, D., Opuda-Asibo, J., Oloya, J. & Skjerve, E. (2010) Distribution and intensity of Echinococcus granulosus infections in dogs in Moroto District, Uganda. Tropical Animal Health and Production 42, 14511457.
Jenkins, D.J. (2006) Echinococcus granulosus in Australia, widespread and doing well! Parasitology International 55 (Suppl.), S203206.
Jenkins, D.J., Romig, T. & Thompson, R.C. (2005) Emergence/re-emergence of Echinococcus spp. – a global update. International Journal for Parasitology 35, 12051219.
Khademvatan, S., Yousefi, E., Rafiei, A., Rahdar, M. & Saki, J. (2013) Molecular characterization of livestock and human isolates of Echinococcus granulosus from south-west Iran. Journal of Helminthology 87, 240244.
Khademvatan, S., Foroutan, M., Hazrati-Tappeh, K., Dalvand, S., Khalkhali, H., Masoumifard, S. & Hedayati-Rad, F. (2017) Toxoplasmosis in rodents: a systematic review and meta-analysis in Iran. Journal of Infection and Public Health. doi: 10.1016/j.jiph.2017.01.021.
Kilic, D., Cangir, A.K., Bulut, S. & Akay, H. (2003) Hydatid cyst of the rib with intramedullary involvement. Acta Chirurgica Belgica 103, 334335.
Lahmar, S., Sarciron, M.E., Rouiss, M. & Mensi, M. (2008) Echinococcus granulosus and other intestinal helminths in semi-stray dogs in Tunisia: infection and re-infection rates. La Tunisie Medicale 86, 657664.
Latif, A.A., Tanveer, A., Maqbool, A., Siddiqi, N., Kyaw-Tanner, M. & Traub, R.J. (2010) Morphological and molecular characterisation of Echinococcus granulosus in livestock and humans in Punjab, Pakistan. Veterinary Parasitology 170, 4449.
Magambo, J., Njoroge, E. & Zeyhle, E. (2006) Epidemiology and control of echinococcosis in sub-Saharan Africa. Parasitology International 55 (Suppl.), S193195.
Mandal, S. & Mandal, M.D. (2012) Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine 5, 253260.
McManus, D.P. (2010) Echinococcosis with particular reference to Southeast Asia. Advances in Parasitology 72, 267303.
McManus, D.P., Zhang, W., Li, J. & Bartley, P.B. (2003) Echinococcosis. Lancet, 362, 12951304.
Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G. & Group, P. (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. International Journal of Surgery 8, 336341.
Moro, P. & Schantz, P.M. (2006a) Cystic echinococcosis in the Americas. Parasitology International 55 (Suppl.), S181186.
Moro, P.L. & Schantz, P.M. (2006b) Echinococcosis: historical landmarks and progress in research and control. Annals of Tropical Medicine and Parasitology 100, 703714.
Moro, P. & Schantz, P.M. (2009) Echinococcosis: a review. International Journal of Infectious Diseases 13, 125133.
Njoroge, E.M., Mbithi, P.M., Gathuma, J.M., Wachira, T.M., Gathura, P.B., Magambo, J.K. & Zeyhle, E. (2002) A study of cystic echinococcosis in slaughter animals in three selected areas of northern Turkana, Kenya. Veterinary Parasitology 104, 8591.
Pawłowski, Z., Eckert, J., Vuitton, D., Ammann, R., Kern, P., Craig, P., Dar, K., Rosa, F.D., Filice, C. & Gottstein, B. (2001) Echinococcosis in humans: clinical aspects, diagnosis and treatment. WHO/OIE manual on echinococcosis in humans and animals: a public health problem of global concern. pp. 2066. Geneva, World Health Organization.
Pednekar, R.P., Gatne, M.L., Thompson, R.C. & Traub, R.J. (2009) Molecular and morphological characterisation of Echinococcus from food producing animals in India. Veterinary Parasitology 165, 5865.
Romig, T., Dinkel, A. & Mackenstedt, U. (2006) The present situation of echinococcosis in Europe. Parasitology International 55 (Suppl.), S187191.
Romig, T., Omer, R.A., Zeyhle, E., Huttner, M., Dinkel, A., Siefert, L., Elmahdi, I.E., Magambo, J., Ocaido, M., Menezes, C.N., Ahmed, M.E., Mbae, C., Grobusch, M.P. & Kern, P. (2011) Echinococcosis in sub-Saharan Africa: emerging complexity. Veterinary Parasitology 181, 4347.
Sadjjadi, S.M. (2006) Present situation of echinococcosis in the Middle East and Arabic North Africa. Parasitology International 55 (Suppl.), S197202.
Saeed, I., Kapel, C., Saida, L.A., Willingham, L. & Nansen, P. (2000) Epidemiology of Echinococcus granulosus in Arbil province, northern Iraq, 1990–1998. Journal of Helminthology 74, 8388.
Sissay, M.M., Uggla, A. & Waller, P.J. (2008) Prevalence and seasonal incidence of larval and adult cestode infections of sheep and goats in eastern Ethiopia. Tropical Animal Health and Production 40, 387394.
Stefanic, S., Shaikenov, B.S., Deplazes, P., Dinkel, A., Torgerson, P.R. & Mathis, A. (2004) Polymerase chain reaction for detection of patent infections of Echinococcus granulosus (‘sheep strain’) in naturally infected dogs. Parasitology Research 92, 347351.
Torgerson, P.R. (2003) Economic effects of echinococcosis. Acta Tropica 85, 113118.
Torgerson, P.R. & Macpherson, C.N. (2011) The socioeconomic burden of parasitic zoonoses: global trends. Veterinary Parasitology 182, 7995.
Torgerson, P.R., Oguljahan, B., Muminov, A.E., Karaeva, R.R., Kuttubaev, O.T., Aminjanov, M. & Shaikenov, B. (2006) Present situation of cystic echinococcosis in Central Asia. Parasitology International 55 (Suppl.), S207212.
Torgerson, P.R., Ziadinov, I., Aknazarov, D., Nurgaziev, R. & Deplazes, P. (2009) Modelling the age variation of larval protoscoleces of Echinococcus granulosus in sheep. International Journal for Parasitology 39, 10311035.
Varcasia, A., Canu, S., Lightowlers, M.W., Scala, A. & Garippa, G. (2006) Molecular characterization of Echinococcus granulosus strains in Sardinia. Parasitology Research 98, 273277.
Varcasia, A., Canu, S., Kogkos, A., Pipia, A.P., Scala, A., Garippa, G. & Seimenis, A. (2007) Molecular characterization of Echinococcus granulosus in sheep and goats of Peloponnesus, Greece. Parasitology Research 101, 11351139.
Wang, Z., Wang, X. & Liu, X. (2008) Echinococcosis in China, a review of the epidemiology of Echinococcus spp. Ecohealth, 5, 115126.
Yang, Y.R., Sun, T., Li, Z. et al. (2006) Community surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China. Bulletin of the World Health Organization 84, 714721.
Yu, S.H., Wang, H., Wu, X.H., Ma, X., Liu, P.Y., Liu, Y.F., Zhao, Y.M., Morishima, Y. & Kawanaka, M. (2008) Cystic and alveolar echinococcosis: an epidemiological survey in a Tibetan population in southeast Qinghai, China. Japanese Journal of Infectious Diseases 61, 242246.
Ziadinov, I., Mathis, A., Trachsel, D., Rysmukhambetova, A., Abdyjaparov, T.A., Kuttubaev, O.T., Deplazes, P. & Torgerson, P.R. (2008) Canine echinococcosis in Kyrgyzstan: using prevalence data adjusted for measurement error to develop transmission dynamics models. International Journal for Parasitology 38, 11791190.
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Prevalence of cystic echinococcosis in Iran: a systematic review and meta-analysis

  • H.R. Khalkhali (a1), M. Foroutan (a2) (a3), S. Khademvatan (a4), H. Majidiani (a2) (a3), S. Aryamand (a3), P. Khezri (a3) and A. Aminpour (a4)...

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