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Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole

Published online by Cambridge University Press:  05 June 2009

K. Nakaya ,
Y. Oomori ,
H. Kutsumi  and
M. Nakao
K. Nakaya*
Affiliation:
Animal Laboratory for Medical Research, Asahikawa Medical College, 3-11 Nishikagura 4-sen 5-go, Asahikawa, Hokkaido 078-8510, Japan
Y. Oomori
Affiliation:
Department of Anatomy, Asahikawa Medical College, 3-11 Nishikagura 4-sen 5-go, Asahikawa, Hokkaido 078-8510, Japan
H. Kutsumi
Affiliation:
Department of Parasitology, Asahikawa Medical College, 3-11 Nishikagura 4-sen 5-go, Asahikawa, Hokkaido 078-8510, Japan
M. Nakao
Affiliation:
Department of Parasitology, Asahikawa Medical College, 3-11 Nishikagura 4-sen 5-go, Asahikawa, Hokkaido 078-8510, Japan
*
*Fax: +81 166 68 2429 E-mail: nky48@asahikawa-med.ac.jp
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Abstract

Using DBA/2J mice, tissue homogenates of larval Echinococcus multilocularis were injected into the mesenteric veins to generate the liver infection. Mice were treated with either albendazole or mebendazole for prolonged periods to examine the morphological changes of the metacestode. Albendazole induced disorganization of both laminated and germinal layers and suppressed the maturation of vesicles. Amorphous but loosely laminated PAS-positive material was observed inside the damaged vesicles, although new vesicles slightly developed inside or outside of the damaged ones. Active proliferation of vesicles occurred after treatment with albendazole was terminated. Hydatid cysts were more severely damaged in mice treated with mebendazole and new vesicles did not develop around the damaged ones. Also, hydatid cysts reappeared after treatment with mebendazole was terminated. These results indicate that these drugs do not eliminate larval E. multilocularis in the long-term, but mebendazole has a higher suppressive effect on multivesiculation than albendazole.

Type
Research Papers
Information
Journal of Helminthology , Volume 72 , Issue 4 , December 1998 , pp. 349 - 354
Copyright
Copyright © Cambridge University Press 1998

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