Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-26T17:21:10.498Z Has data issue: false hasContentIssue false
  • English
  • Français

Migration and development of the larvae of Gnathostoma nipponicum in the rat, second intermediate or paratenic host, and the weasel, definitive host

Published online by Cambridge University Press:  05 June 2009

K. Ando ,
Y. Sato ,
K. Miura ,
H. Matsuoka  and
Y. Chinzei
K. Ando
Affiliation:
Department of Medical Zoology, Mie University School of Medicine, Tsu 514, Japan
Y. Sato
Affiliation:
Department of Medical Zoology, Mie University School of Medicine, Tsu 514, Japan
K. Miura
Affiliation:
Department of Medical Zoology, Mie University School of Medicine, Tsu 514, Japan
H. Matsuoka
Affiliation:
Department of Medical Zoology, Mie University School of Medicine, Tsu 514, Japan
Y. Chinzei
Affiliation:
Department of Medical Zoology, Mie University School of Medicine, Tsu 514, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

Migration and development of the larvae of Gnathostoma nipponicum in the rat as second intermediate or paratenic host and the weasel as definitive host were examined to clarify the pathogenesis in each animal. The advanced third-stage larvae (AdL3) given orally to rats remained in the stomach for 12 h post-infection (PI). After that, larvae transiently invaded various organs and finally moved into the muscle within 48 h. The percentage of eosinophils in the blood taken from the jugular vein of rats infected with AdL3 reached a maximum (about 6%) on day 20 PI and then decreased. IgG antibody titre for G. nipponicum measured by ELISA began to increase on day 5 PI and reached a plateau on day 20 PI. The AdL3 given orally to weasels moved from the stomach into the muscle and then increased in size. Half of them invaded the muscle within 5 days, whereas the majority of them invaded the muscles within 20 days PI. Morphology of worms which invaded the muscles indicated that they were still the larval form with three rows of hooklets on the head bulb. The larvae in the muscles developed to young adult worms with seven rows of hooklets on the head bulb within 40 days PI. These young adult worms invaded the oesophageal wall and formed a tumour within 60 days PI. It was presumed that worms invaded the oesophageal wall though the adventitia. Ferret and mink were shown to be potential final hosts of G. nipponicum.

Type
Research Papers
Information
Journal of Helminthology , Volume 68 , Issue 1 , March 1994 , pp. 13 - 17
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ando, K., Tanaka, H., Taniguchi, Y., Shimizu, M. & Kondo, K. (1988) Two human cases of gnathostomiasis and discovery of a second intermediate host of Gnathostoma nipponicum in Japan. Journal of Parasitology 74, 623–627.CrossRefGoogle ScholarPubMed
Ando, K., Tanaka, Y. & Chinzei, Y. (1989) Influence of temperature on development of eggs and larvae of Gnathostoma nipponicum Yamaguti, 1941. Japanese Journal of Parasitology 38, 31–37.Google Scholar
Ando, K., Hatsushika, R., Akahane, H., Matsuoka, H., Taylor, D., Miura, K. & Chinzei, Y. (1991) Gnathostoma nipponicum infection in the past human cases in Japan. Japanese Journal of Parasitology 40, 184–186.Google Scholar
Ando, K., Tokura, H., Matsuoka, H., Taylor, D. & Chinzei, Y. (1992) Life cycle of Gnathostoma nipponicum Yamaguti, 1941. Journal of Helminthology 66, 53–61.CrossRefGoogle ScholarPubMed
Arita, M. (1953) Studies on two species of Gnathostoma parasitic in the weasels. Acta Medica (Fukuoka) 23, 1729–1749. (In Japanese)Google Scholar
Isobe, H. (1952) Studien uber den Endwirt von Gnathostoma. report 2 Ueber die Entwicklung und die Migrationswege in dem Endwirt des Gnathostoma spinigerum. Acta Medica (Fukuoka) 22, 1524–1534. (In Japanese)Google Scholar
Koga, M. & Ishii, Y. (1981) Larval gnathostomes found in reptiles in Japan and experimental life cycle of Gnathostoma nipponicum. Journal of Parasitology 67, 565–570.CrossRefGoogle Scholar
Mabuchi, S. (1956) Development of the ova of Gnathostoma nipponicum. Acta Scholae Medicinalis in Gifu 3, 452–458. (In Japanese)Google Scholar
Mabuchi, S. (1957) Studies on the development of the larva of Gnathostoma nipponicum in Eucyclops serrulatus. Acta Scholae Medicinalis in Gifu 4, 587–636. (In Japanese with English summary)Google Scholar
Miyazaki, I. & Umetani, T. (1950) A morphological study of Gnathostoma nipponicum parasitic in the weasel in Kyushu. Japanese Journal of Clinical Experimental Medicine 27, 112–116. (In Japanese)Google Scholar
Nishikubo, K. (1961) Studies on experimental gnathostomiasis, with special reference to host-parasite relationship in G. spinigerum. Endemic Disease Bulletin of Nagasaki University 3, 198–204. (In Japanese)Google Scholar
Sagara, I. (1953a) Studies on Gnathostoma. Part I. A pathohistologic study of the site of adult gnathostome infestation in final hosts. Acta Medica (Fukuoka) 23, 800–821. (In Japanese)Google Scholar
Sagara, I. (1953b) Studies on Gnathostoma. Part II. Migration route of larvae of Gnathostoma spinigerum in the rat's body and histopathological changes caused along the route. Acta Medica (Fukuoka) 23, 822–835. (In Japanese)Google Scholar
Sato, H., Kamiya, H. & Hanada, K. (1992) Five confirmed human cases of gnathostomiasis nipponica recently found in northern Japan. Journal of Parasitology 78, 1006–1010.CrossRefGoogle ScholarPubMed
Takakura, Y. (1988) Experimental studies on Gnathostoma hispidum Fedschenko, 1872: migration and development of the larvae in the rats and piglets. Japanese Journal of Parasitology 37, 67–75. (In Japanese)Google Scholar
Umetani, T. & Arita, M. (1951) Adult and larvae of Gnathostoma parasitic in the weasel in Kyushu. Medicine and Biology 18, 154–157. (In Japanese)Google Scholar
Yamaguti, S. (1941) Studies on the helminth fauna of Japan. Part 35. Mammalian nematodes II. Japanese Journal of Zoology 9, 409–440.Google Scholar