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The involvement of eggs and soluble egg antigens in resistance to Schistosoma japonicum

Published online by Cambridge University Press:  05 June 2009

N. A. Moloney ,
A. J. F. Luty ,
P. Hinchcliffe  and
G. Webbe
N. A. Moloney
Affiliation:
Winches Farm Field Station, 395, Hatfield Road, St. Albans, Herts, AL3 OXQ, England
A. J. F. Luty
Affiliation:
Winches Farm Field Station, 395, Hatfield Road, St. Albans, Herts, AL3 OXQ, England
P. Hinchcliffe
Affiliation:
Winches Farm Field Station, 395, Hatfield Road, St. Albans, Herts, AL3 OXQ, England
G. Webbe
Affiliation:
Winches Farm Field Station, 395, Hatfield Road, St. Albans, Herts, AL3 OXQ, England
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Abstract

Mice presensitized with SEA and subsequently injected with S. japonicum eggs into their lungs or liver developed pathology similar to that found in infected mice and were consequently resistant to challenge (average 33% and 53%, respectively). However, soluble egg antigens were also capable of inducing low levels of resistance in mice (average 22·5%), but intact eggs alone injected into the lungs, liver or subcutance tissues were not. Thus, prior sensitization to ‘marginally’ protective soluble egg antigens is necessary for egg induced resistance.

Keywords

Schistosoma japonicumimmunizationresistanceegg injectionsoluble egg antigens
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 1 , March 1987 , pp. 9 - 17
Copyright
Copyright © Cambridge University Press 1987

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References

REFERENCES

Bickle, Q.D., Bain, J., McGregor, A., Doenhoff, M.J. (1979) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. III. The failure of primary infections with cercariae of one sex to induce resistance to reinfection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 37–41.CrossRefGoogle ScholarPubMed
Bickle, Q.D., Long, E., James, E. & Doenhoff, M.J. (1980) Schistosoma mansoni: Influence of the mouse host's sex, age and strain on resistance to reinfection. Experimental Parasitology, 50, 222–252.CrossRefGoogle ScholarPubMed
Cheever, A.W. (1968) Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissue. Bulletin of the World Health Organization, 39, 328–331.Google Scholar
Dean, D.A. (1983) A review. Schistosoma and related genera: Acquired resistance in mice. Experimental Parasitology, 55, 1–104.CrossRefGoogle ScholarPubMed
Dean, D.A., Minard, P., Murrell, K.D. & Vannier, W.E. (1978) Resistance of mice to secondary infection with Schisitosoma mansoni. II. Evidence for a correlation between egg deposition and worm elimination. American Journal of Tropical Medicine and Hygiene, 27, 957–965.CrossRefGoogle Scholar
Doenhoff, M.J., Pearson, S., Dunne, D.W., Bickle, Q.D., Lucas, S., Bain, J. & Hassounah, O. (1981) Immunological control of hepatotoxicity and parasite egg excretion in Schistosoma mansoni infections: Stage specificity of the reactivity of immune serum in T-cell deprived mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75, 41–53.CrossRefGoogle ScholarPubMed
Dunne, D.W., Lucas, S., Bickle, Q.D., Pearson, S., Madgwick, L., Bain, J. & Doenhoff, M.J. (1981) Identification and partial purification of an antigen (ω1) from Schistosoma mansoni eggs which is putatively hepatoxic in T-cell deprived mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75, 54–71.CrossRefGoogle Scholar
Edungbola, L.D. & Schiller, E.L. (1979) The histopathology of hepatic and pulmonary granulomata experimentally induced with eggs of Schistosoma mansoni. Journal of Parasitology, 65 253–261.CrossRefGoogle ScholarPubMed
Harrison, R.A., Bickle, Q.D. & Doenhoff, M.J. (1982) Factors affecting the acquisition of resistance Schistosoma mansoni in the mouse. Evidence that the mechanisms which mediate resistance during early patent infections may lack immunological specificity. Parasitology, 84, 93–110.CrossRefGoogle ScholarPubMed
Long, E., Harrison, R., Bickle, Q.D., Bain, J.Nelson, G. & Doenhoff, M.J. (1980) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. The effects of varying the route and the number of primary infections and the correlation between the size of the primary infection and the degree of resistance that is acquired. Parasitology, 81, 355–371.CrossRefGoogle ScholarPubMed
Lowry, O.H., Rosenbrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the folin phenol reagent. Jounral of Biological Chemistry. 193, 265–275.CrossRefGoogle ScholarPubMed
Moloney, N.A. & Webbe, G. (1982) A rapid method for the infection of laboratory mice with Schistosoma japonicum. Transactions of the Royal Socity of Tropical Medicine and Hygiene, 76, 200–203.CrossRefGoogle ScholarPubMed
Moloney, N.A. & Webbe, G. (1983) The host-parasite relationship of Schistosoma japonicum in CBA mice. Parasitology, 87, 327–342.CrossRefGoogle ScholarPubMed
Moloney, N.A. & Webbe, G. (1984) Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. II. Evidence that resistance to reinfection is not mediated by specific effector mechanisms. Parasitology, 89, 361–367.CrossRefGoogle Scholar
Moloney, N.A. & Webbe, G. (1984) Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. II. Evidence that resistance to reinfection is not mediated by specific effector mechanisms. Parasitology, 89, 361–367.CrossRefGoogle Scholar
Moloney, N.A., Webbe, G. & Luty, A.J. (1984) Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. I. The correlation between egg deposition and worm elimination. Parasitology, 89, 345–360.CrossRefGoogle ScholarPubMed
Murrell, K.D., Clark, S., Dean, D.A. & Vannier, W.E. (1979) Influence of mouse strain on induction of resistance with irradiated Schistosoma mansoni cercariae. Journal of Parasitology, 65, 829–831.CrossRefGoogle ScholarPubMed
Ritchie, L.S., Garson, S. & Erickson, D.G. (1962) Attempts to induce resistance against Schistosoma mansoni by injecting cercarial. adult worm, and egg homogentes in sequence. Journal of Parasitology, 48, 233–236.CrossRefGoogle Scholar
Smithers, S.R. & Terry, R.J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology, 55, 695–700.CrossRefGoogle ScholarPubMed
Wilson, R.A., Coulson, P.S. & McHugh, S.M. (1983) A significant part of the ‘conomitant immunity’ of mice to Schistosoma mansoni is the consequence of a leaky hepatic portal system, not immune killing. Parasite Immunology, 5, 595–601.CrossRefGoogle Scholar