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Induction of host resistance to Brugia pahangi in jirds (Meriones unguiculatus) protected by chemoprophylaxis

Published online by Cambridge University Press:  05 June 2009

W. Chusattayanond  and
D. A. Denham
W. Chusattayanond
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
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Abstract

Jirds were given a chcmoprophylactic inoculation of flubendazole (FMBZ) and then five injections of infective larvae of Brugia pahangi whilst still protected by the FMDZ. When the drug was thought to be noneffective the jirds (and controls) were given a challenge infection of B. pahangi larvae. By comparison with control jirds the trcatcd-infectcd-challcnged jirds had 40% fewer adult worms. The control treated-challenged jirds contained mostly sterile female worms showing that they were still partially protected by FMBZ but worms numbers were not significantly reduced as compared with untreated controls.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 245 - 249
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Au, A.C.S., Denham, D.A., Steward, M.W., Draper, C.C., Ismail, M.M., Rao, C.K. &Mak, J.W. (1981) Detection of circulating antigens and immune complexes in feline and human lymphatic filariasis. Southeast Asian Journal of Tropical Medicine and Public Health, 12, 492–498.Google Scholar
Blair, L.S. & Campbell, W.C. (1981) Immunization of ferrets against Dirofilaria immitis by means of chemically abbreviated infections. Parasite Immunology, 3, 143–147.CrossRefGoogle ScholarPubMed
Chusattayanond, W. & Denham, D.A. (1984) Chemoprophylactic activity of flubcndazolc against Brugia pahangi in jirds. Journal of Parasitology, 70 (in press).CrossRefGoogle ScholarPubMed
Denham, D.A. (1982) The methodology of screening for filarial activity using Brugia pahangi. In: Animal Models in Parasitology (Ed. Owen, D.), pp. 93–104. London: Macmillan.Google Scholar
Denham, D.A., Samad, R., Cho, S-Y., Suswillo, R.R. & Skippins, S.C. (1979) The anthelmintic effects of flubcndazolc on Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 673–676.Google Scholar
Denham, D.A., Suswillo, R.R. & Chusattayanond, W. (1983 Parasitological observations on Meriones unguiculatus singly or multiply infected with Brugia pahangi. Parasitology, 86, 11–18.Google Scholar
Karavodin, L.M. & Ash, L.R. (1980) Circulating immune complexes in experimental filariasis. Clinical Experimental Immunology, 40, 312–317.Google Scholar
Mccall, J.W., Jun, J. & Dalesandro, D. (1978) Immunogenicity of developing larvae of Brugia pahangi attenuated in vivo by treatment of infected jirds with mebendazole. The Association of Southern Biologists Bulletin, 25, 60.Google Scholar
Ottesen, E.A., Weller, P.F. &Heck, L. (1977) Specific cellular immune unresponsiveness in human filariasis. Immunology, 33, 413–421.Google Scholar
Ottesen, E.A., Weller, P.R., Lunde, M.N. & Hussain, R. (1982) Endemic filariasis on a Pacific Island. II. Immunologic aspects: immunoglobulin, complement, and specific antifilarial IgG, IgM and igE antibodies. American Journal of Tropical Medicine and Hygiene, 31, 953–961.CrossRefGoogle ScholarPubMed