Skip to main content Accessibility help

Immunodepression in hamsters experimentally infected with Opisthorchis viverrini

  • S. Wongratanacheewin (a1), W. Rattanasiriwilai (a1), R. Priwan (a1) and S. Sirisinha (a1)


Hamsters experimentally infected with Opisthorchis viverrini had significant depression of the antibody response to sheep red blood cells. The depression was more severe with prolonged infections. Lymphoproliferative response to phytohaemagglutinin stimulation was also depressed when compared with uninfected controls. The immunodepression in these animals was abolished by anthelmintic treatment, suggesting that the immunodepressive effect is reversible and is associated with active infection.


Corresponding author

*For all correspondence


Hide All
Alekseeva, M. I., Boglazova, E. K., Lebedev, K. A. & Lukashenko, T. N. (1980). Suppression of macrophages in trematode infections. In: 9 Konferentsiya Ukrainskogo Parazitologicheskogo Obshchestva Tezisy dokladov Chast'l. pp. 2122, Kiev, U.S.S.R.
Bauminger, S. & Peleg, S. (1978). Changes in immunological activity of rat lymphoid organ during pregnancy. Clinical and Experimental Immunology, 32, 179185.
Boyum, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Laboratory and Clinical Investigation, 21, (Suppl 97), 7789.
Cunninghama, J. & Szenberg, A. (1968). Further improvements in the plaque technique for detecting single antibody-forning cells. Immunology, 14, 599600.
Fox, R. H., Dudley, F. J., Samuels, M., Milligan, J. & Sherlock, S. (1973). Lymphocyte transformation in response to phytohaemagglutinin in primary biliary cirrhosis. The search for a plasma inhibiting factor. Gut, 14, 8993.
Goose, J. (1978). Possible role of excretory/secretory products in evasion of host defenses by Fasciola hepatica. Nature, 275, 216217.
Hsu, C. C. S. & Leevy, C. M. (1971). Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis. Clinical and Experimental Immunology, 8, 749760.
Nakao, M., Mizoguchi, Y., Monna, T., Yamamoto, S. & Morisawa, S. (1978). Studies on an inhibitory factor to phytohemagglutinin-induced lymphocyte transformation found in the serum of patients with various liver diseases. Acta Hepato-Gastroenterologica, 25, 335343.
O'keefe, S. J., El-zayadi, A. R., Carraher, T. E., Davis, M. & Williams, R. (1980). Malnutrition and immunoincompetence in patients with liver disease. Lancet, 2, 615617.
Sirisinha, S., Tuti, S., Tawatsin, A. & Rattanasiriwilai, W. (1982). Lack of evidence for protective immunity in hamsters infected with Opisthorchis viverrini. In: Immunology of Tropical Parasitic Infections in Asia and Pacific Region, (editors, Mak, J. W. & Yong, H. S.). pp. 91100. Kuala Lumpur.
Sirisinha, S., Tuti, S., Vichasri, S. & Tawatsin, A. (1983). Humoral immune responses in hamsters infected with Opisthorchis viverrini. Southeast Asian Journal of Tropical Medicine and Public Health, 14, 243251.
Smithers, S. R. & Doenhoff, M. J. (1982). Schistosomiasis. In: Immunology of Parasitic Infection, (editors, Cohen, S. & Warren, K. S.). 2nd edition, pp. 527607. Blackwell Scientific Publications: London.
Sun, T. & Gibson, J. B. (1969). Antigens of Clonorchis sinensis in experimental and human infections. American Journal of Tropical Medicine and Hygiene, 18, 241252.
Tawatsin, A., Sirisinha, S., Vajrasthira, S., Bunnag, D. & Harinasuta, T. (1984). Evaluation of selected anthelmintic compounds for activity against Opisthorchis viverrini. Tropenmedizin und Parasitologie, 35, 8590.
Terry, R. & Hudson, K. (1982). Immunodepression in parasitic infections. Fortshritte der Zoologie, 27, 125139.
Zimmerman, G. L., Isaacson kerkvliet, N., Brauner, J. A. & Cerro, J. E. (1983). Modulation of host immune responses by Fasciola hepatica: responses of peripheral lymphocytes to mitogens during liver fluke infections of sheep. Journal of Parasitology, 69, 473477.


Immunodepression in hamsters experimentally infected with Opisthorchis viverrini

  • S. Wongratanacheewin (a1), W. Rattanasiriwilai (a1), R. Priwan (a1) and S. Sirisinha (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed