Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-23T10:44:53.812Z Has data issue: false hasContentIssue false
  • English
  • Français

Enhancement of intestinal eosinophilia during Hymenolepis nana infection in mice

Published online by Cambridge University Press:  05 June 2009

A. Niwa  and
T. Miyazato
A. Niwa
Affiliation:
Department of Parasitology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka 589, Japan
T. Miyazato
Affiliation:
Department of Parasitology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka 589, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

The ability of Hymenolepis nana oncosphere extract to induce eosinophil chemotactic response was examined in vitro and in vivo. The extract showed a chemotactic activity specific for eosinophils but not for neutrophils. Partially purified eosinophil chemotactic factors (ECFs) from the oncosphere extract showed apparent molecular mass from 5.5 to 9.6kDa and 30 to 40kDa. These were resistant to heating and proteinase K digestion but sensitive to periodate oxidation. Peritoneal injection of the crude extract or partially purified ECFs to mice resulted in a preferential eosinophil infiltration. The chemotactic activity for eosinophils was not separable from the adhesion molecule expression or oxygen radical-inducing activity by means of chromatography or chemical treatments. Furthermore, histological examination demonstrated a marked tissue eosinophilia around H. nana larvae in the intestinal lamina propria of both humoral and cell-mediated immunodeficiency mice. The present findings suggest that H. nana oncosphere-derived molecules facilitate in vivo the intestinal eosinophilia during the infection.

Type
Research Papers
Information
Journal of Helminthology , Volume 70 , Issue 1 , March 1996 , pp. 33 - 41
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ansari, A. & Williams, J.F. (1976) The eosinophilic response of the rat to infection with Taenia taeniaeformis. journal of Pamsitology 62, 728–736.Google Scholar
Arnaout, M.A. (1990) Structure and function of the leukocyte adhesion molecules CD11 /CD18. Blood 75, 1037–1050.CrossRefGoogle Scholar
Asano, K., Murakami, K. & Okamoto, K. (1993) Lymphokine production by mesenteric lymph node cells from BALB/c mice during Hymenolepis nana infection. International Journal for Parasitology 23, 51–56.Google Scholar
Carlos, T.M. & Harlan, J.M. (1994) Leukocyte-endothelial adhesion molecules. Blood 84, 2068–2101.Google Scholar
Cho, C. & Patel, S.P. (1978) Human sparganosis in northern United States. New York State Journal of Medicine 78, 1456–1458.Google Scholar
Cook, R.W. & Williams, J.F. (1981) Pathology of Taenia taeniaeformis infection in the rats. Gastrointestinal changes. Journal of Comparative Pathology 91, 205–217.CrossRefGoogle ScholarPubMed
Furukawa, T. (1974) Adherence reactions with mouse lymphoid cells against the oncosphere larvae of Hymenolepis nana. Japanese Journal of Parasitology 23, 236–249.Google Scholar
Horii, Y., Owhashi, M., Ishii, A., Bandou, K. & Usui, M. (1984) Leukocyte accumulation in sparganosis: Demonstration of eosinophil and neutrophil chemotactic factors from the plerocercoid of Spirometra erinacei in vivo and in vitro. American Journal of Tropical Medicine and Hygiene 33, 138–143.Google Scholar
Horii, Y., Owhashi, M., Fujita, K., Nakanishi, H. & Ishii, A. (1988) A comparative study on eosinophil and neutrophil chemotactic activities of various helminth parasites. Parasitology Research 75, 76–78.Google Scholar
Imamura, M., Aoki, N., Saito, T., Ohno, Y, Maruyama, Y., Yamaguchi, J. & Yamamoto, T. (1986) Inhibitory effects of antithyroid drugs on oxygen radical formation in human neutrophils. Acta Endocrinologica 112, 210–216.Google ScholarPubMed
Ishida, K. & Yoshimura, K. (1990) Differences in responses of rat- and guinea-pig-eosinophils to eosinophil chemotactic factors derived from Angiostrongylus cantonensis. Parasite Immunology 12, 269–283.Google Scholar
Ito, A., Honey, R.D., Scanlon, T., Lightowlers, M.W. & Rickard, M.D. (1988) Analysis of antibody responses to Hymenolepis nana infection in mice by the enzyme-linked immunosorbent assay and immunopretipitation. Parasite Immunology 10, 265–277.Google Scholar
Litt, M. (1963) Studies in experimental eosinophilia. American Journal of Pathology 42, 529–549.Google Scholar
Lo, S.K., Janakidevi, K., Lai, L. & Malik, A.B. (1993) Hydrogen peroxide induced increase in endothelial adhesiveness is dependent on ICAM-1 activation. American Journal of Physiology 264, L406–L412.Google Scholar
Marui, N., Offermann, M.K., Swerlick, R., Kunsch, C., Rosen, C.A., Ahmad, M., Alexander, R.W. & Medford, R.M. (1993) Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. Journal of Clinical Investigation 92,1866–1874.CrossRefGoogle ScholarPubMed
Miyawaki, S., Nakamura, Y., Suzuka, H., Koba, M., Yasumizu, R., Ikehara, S. & Shibata, Y. (1994) A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. European Journal of Immunology 24, 429–434.CrossRefGoogle ScholarPubMed
Miyazato, T., Furukawa, T. & Inoue, T. (1979) Intestinal pathology associated with primary and secondary infections of Hymenolepis nana in mice. Japanese Journal of Parasitology 28, 185–195.Google Scholar
Natarajan, V. (1995) Oxidants and signal transducrion in vascular endothelium. Journal of Laboratory and Clinical Medicine 125, 26–37.Google ScholarPubMed
Owhashi, M. & Ishii, A. (1982) Purification and characterization of a high molecular weight eosinophil chemotactic factor from Schistosoma japonicum eggs. Journal of Immunology 129, 2226–2231.Google Scholar
Potter, K.A. & Leid, R.W. (1986) Isolation and partial characterization of an eosinophil chemotactic factor from metacestodes otTaenia taeniaeformis. Journal of Immunology 136, 1712–1717.CrossRefGoogle ScholarPubMed
Resnick, M.B. & Weller, P.P. (1993) Mechanisms of eosinophil recruitment. American Journal of Respiratory Cell and Molecular Biology 8, 349–355.CrossRefGoogle ScholarPubMed
Richard, S., Farrell, C.A., Shaw, A.S., Showell, H.J. & Connelly, P.A. (1994) C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil. Journal of Immunology 152, 2479–2487.CrossRefGoogle Scholar
Rollins, B.J., Walz, A. & Baggiolini, M. (1991) Recombinant human MCP-l/JE induces chemotaxis, calcium influx, and the respiratory burst in human monocytes. Blood 78, 1112–1116.Google Scholar
Sanderson, C.J. (1993) Cytokines active on eosinophils. pp.274–283 in Makino, S. & Fukuda, T. (Eds) Eosinophils: biological and clinical aspects. Boca Raton, CRC Press.Google Scholar
Shimoda, K., Furukawa, T. & Miyazato, T. (1982) Clinicopathological changes of mice following primary and secondary infections with Hymenolepis nana eggs. 1. Changes in hematological values. Japanese Journal of Parasitology 31, 203–210.Google Scholar
Vadas, M.A., Shannon, M.F., Lopez, A.F. & Sewell, W.A. (1993) Mechanisms of eosinophilia in parasitic infestation, pp. 285–301 in Makino, S. & Fukuda, T. (Eds) Eosinophils: biological and clinical aspects. Boca Raton, CRC Press.Google Scholar
Wardlaw, A.J., Moqbel, R., Cromwell, O. & Kay, A.B. (1986) Platelet-activating factor: a potent chemotactic and chemokinetic factor for human eosinophils. Journal of Clinical Investigation 78, 1701–1706.Google Scholar
Warren, K.S., Boros, D.L., Hang, L.M. & Mahmoud, A.A.F. (1975) The Schistosoma japonicum egg granuloma. American Journal of Pathology 80, 279–294.Google Scholar
Yoshimura, K., Sugaya, H., Kawamura, K. & Kumagai, M. (1988) Ultrastractural and morphometric analysis of eosinophils from the cerebrospinal fluid of the mouse and guinea-pig infected with Angiostrongylus cantonensis. Parasite Immunology 10, 411–423.CrossRefGoogle Scholar
Zigmond, S.H. & Hirsch, I.G. (1973) Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factors. Journal of Experimental Medicine 137, 387–410.CrossRefGoogle Scholar