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Efficacy of herbal extracts and closantel against fenbendazole-resistant Haemonchus contortus

  • A.K. Dixit (a1), G. Das (a1), P. Dixit (a2) and R.L. Sharma (a3)

Abstract

This study assessed the efficacy of closantel vis-à-vis herbal extracts with known anti-parasitic properties, against fenbendazole-resistant nematodes in goats maintained under a semi-intensive system of management at the University goat farm, Jabalpur. Fifty goats were randomly assigned to five groups, each comprising 10 animals, irrespective of their breed, age and sex. Each animal in Group I, II and III was orally administered with aqueous leaf extracts of neem (Azadirachta indica) at 1 g/kg body weight, sitaphal (Annona squamosa) at 1.5 g/kg body weight and tobacco (Nicotiana tabacum) at 1 g/kg body weight, respectively, whereas Group IV was an untreated control group. Each animal in Group V was orally treated with closantel at 10 mg/kg body weight. During the course of the study, all animals were maintained under an identical semi-intensive system of management. Compared to the untreated control group (Group IV), there was no conspicuous reduction in post-treatment (day 10) faecal egg counts (FEC) in animals administered with the herbal extracts (Groups I, II and III), which is suggestive of poor anti-parasitic activity. However, using the faecal egg count reduction test (FECRT), the overall efficacy of closantel was recorded as 95.64%. This supports the rotational use of closantel as a preferred choice over the benzimidazole group of anthelmintics and/or herbal extracts to meet the acute challenge of in situ development of drug-resistant gastrointestinal nematodes, especially Haemonchus contortus.

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Corresponding author

Author for correspondence: A.K. Dixit, E-mail: alokdixit7@yahoo.com

References

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Akhtar, MS and Riffat, S (1984) Efficacy of Melia azedarach linn. (Bakain) and morantel against naturally acquired gastro-intestinal nematodes in goats. Pakistan Veterinary Journal 4, 176179.
Chagas, ACS and Vieira, LS (2007) Açao de Azadirachta indica (Neem) em nematódeos gastrintestinais de caprinos. Brazilian Journal of Veterinary Research and Animal Science 44, 4955.
Chandrawathani, P et al. (2006) Daily feeding of fresh neem leaves (Azadirachta indica) for worm control in sheep. Journal of Tropical Biomedicine 23, 2330.
Chandrawathani, P et al. (2013a) Testing neem products on goats in Infoternak, Perak: a preliminary trial for neem capsules, neem juice, neem extract and neem decoction for worm control. Malaysian Journal of Veterinary Research 4, 3339.
Chandrawathani, P et al. (2013b) Severe anthelmintic resistance in two free grazing small holder goat farms in Malaysia. Journal of Veterinary Science & Technology 4, 137.
Coles, GC et al. (1992) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary Parasitology 44, 3544.
Das, G et al. (2015) Levamisole and fenbendazole resistance in gastrointestinal nematodes in goats at Jabalpur, Madhya Pradesh. Journal of Veterinary Parasitology 29, 98102.
Dhar, DN, Sharma, RL and Bansal, GC (1982) Gastrointestinal nematodes in sheep in Kashmir. Veterinary Parasitology 11, 271277.
Dixit, AK et al. (2017) An assessment of benzimidazole resistance against caprine nematodes in Central India. Tropical Animal Health & Production 49, 14711478.
Dongre, S et al. (2015) Anthelmintic efficacy of Azadirachta indica (neem) against strongyles in goats. Indian Journal of Veterinary Science & Biotechnology 10, 1821.
FAO (2015) The Second Report on the State of the World's Animal Genetic Resources for Food and Agriculture, Scherf, BD and Pilling, D (eds). FAO Commission on Genetic Resources for Food and Agriculture Assessments, Rome (available at http://www.fao.org/3/a-i4787e/index.html).
Ferreira, LE et al. (2013) In vitro anthelmintic activity of aqueous leaf extract of Annona muricata l. (annonaceae) against Haemonchus contortus from sheep. Experimental Parasitology 134, 327332.
Githiori, JB et al. (2004) Evaluation of anthelmintic properties of some plants used as livestock dewormers against Haemonchus contortus infections in sheep. Parasitology 129, 245253.
Hamad, KK et al. (2013) Antinematicidal activity of Nicotiana tabacum L. leaf extracts to control benzimidazole-resistant Haemonchus contortus in sheep. Pakistan Veterinary Journal 33, 8590.
Iqbal, Z et al. (2006) In vitro and in vivo anthelmintic activity of Nicotiana tabacum L. leaves against gastrointestinal nematodes of sheep. Phytotherapy Research 20, 4648.
Kamaraj, C and Rahuman, AA (2011) Efficacy of anthelmintic properties of medicinal plant extracts against Haemonchus contortus. Research in Veterinary Science 91, 400404.
Lanusse, CE, Guillermo, LV and Alvarez, LI (2009) Anticestodal and antitrematodal drugs. In Riviere, JE and Papich, MG (eds), Veterinary Pharmacology & Therapeutics, 9th edn. Ames, IA: Wiley-Blackwell, pp. 11041106.
McLeod, RS (2004) Economic impact of worm infections in small ruminants in South East Asia, India and Australia. In Sani, RA, Gray, GD and Baker, RL (eds), Worm Control of Small Ruminants in Tropical Asia. ACIAR Monograph 113. Canberra: Australian Centre for International Agricultural Research, pp. 2333.
Nawaz, M et al. (2014) In vitro and in vivo anthelmintic activity of leaves of Azadirachta indica, Dalbergia sisso and Morus alba against Haemonchus contortus. Global Veterinaria 13, 9961001.
Ndjonka, D et al. (2011) In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocerca ochengi) and free-living (Caenorhabditis elegans) nematodes. Journal of Helminthology 85, 304312.
Premaalatha, B et al. (2014) Anthelmintic resistance in small ruminant farms: an ongoing challenge for perak farmers to control helminths. Malaysian Journal of Veterinary Research 5, 3138.
Santos, MC, Silva, BF and Amarante, AFT (2012) Environmental factors influencing the transmission of Haemonchus contortus. Veterinary Parasitology 188, 277284.
Singh, D, Swarnkar, CP and Khan, FA (2002) Anthelmintic resistance in gastrointestinal nematodes of livestock in India. Journal of Veterinary Parasitology 16, 115130.
Swarnkar, CP et al. (2008) Epidemiology and Management of Gastrointestinal Parasites of Sheep in Rajasthan, 1st edn. Avikanagar: Central Sheep and Wool Research Institute, pp. 3857.
Van Wyk, JA, Cabaret, J and Michael, LM (2004) Morphological identification of nematode larvae of small ruminants and cattle simplified. Veterinary Parasitology 119, 277306.
Vieira, LS et al. (1999) Evaluation of anthelmintic efficacy of plants available in Ceará State, north-east Brazil, for the control of goat gastrointestinal nematodes. Revista de Medicina Veterinaria 150, 447452.
Westers, T et al. (2016) Efficacy of closantel against ivermectin- and fenbendazole-resistant Haemonchus sp. in sheep in Ontario, Canada. Veterinary Parasitology 228, 3041.
Worku, M, Franco, R and Miller, JH (2009) Evaluation of the activity of plant extracts in Boer goats. American Journal of Animal & Veterinary Sciences 4, 7279.
Zajac, AM and Conboy, GA (2012) Veterinary Clinical Parasitology, 8th edn. Chichester: UK, pp. 3170.

Keywords

Efficacy of herbal extracts and closantel against fenbendazole-resistant Haemonchus contortus

  • A.K. Dixit (a1), G. Das (a1), P. Dixit (a2) and R.L. Sharma (a3)

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