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Effects of recombinant bovine interferon γ on Strongyloides papillosus infection in calves

Published online by Cambridge University Press:  12 April 2024

Y. Nakamura ,
T. Syouji ,
T. Onodera ,
K. Kawashima ,
S. Inumaru  and
Y. Yokomizo
Y. Nakamura*
Affiliation:
Shichinohe Research Unit, National Institute of Animal Health, Shichinohe, Aomori 039-2586, Japan
T. Syouji
Affiliation:
Shichinohe Research Unit, National Institute of Animal Health, Shichinohe, Aomori 039-2586, Japan
T. Onodera
Affiliation:
Shichinohe Research Unit, National Institute of Animal Health, Shichinohe, Aomori 039-2586, Japan
K. Kawashima
Affiliation:
Shichinohe Research Unit, National Institute of Animal Health, Shichinohe, Aomori 039-2586, Japan
S. Inumaru
Affiliation:
National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan
Y. Yokomizo
Affiliation:
National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan
*
*Address for correspondence: International Livestock Research Institute, PO Box 30709, Nairobi, Kenya. Fax: +254 2 631499 Email: y.nakamura@cgiar.org
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Abstract

The effects of interferon (IFN) γ on the course of infection with Strongyloides papillosus in calves were investigated. Calves (N=7 each) were inoculated with recombinant bovine IFNγ or control solution daily from day 0 to day 15 following S. papillosus infection. Treatment with IFNγ induced an increase in faecal egg output in the peak stage of infection. The IFNγ-treated animals harboured more worms, especially more immature worms, in the small intestine than control animals at necropsy on day 17, with no decreases in intestinal mucosal mast cells. Both animal groups had similar small numbers of intestinal worms at necropsy on day 26. All control animals developed peripheral blood eosinophilia on day 7, while five of seven IFNγ-treated animals did not. Serum α1-acid glycoprotein concentrations increased on day 7 in both animal groups, with higher values in control animals than in IFNγ-treated animals. Control animals mounted a predominant IgG1 response to S. papillosus from day 10, while IFNγ-treated animals did from day 22. These data suggested that IFNγ inhibited some host protective responses to S. papillosus migrating larvae, resulting in an improvement of worm survival after a period when protective responses should be activated during the early stage of infection. The effects of IFNγ on intestinal worm expulsion should be confirmed by further experiments.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 1 , March 2002 , pp. 59 - 64
Copyright
Copyright © Cambridge University Press 2002

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