Hostname: page-component-8448b6f56d-sxzjt Total loading time: 0 Render date: 2024-04-19T19:43:27.293Z Has data issue: false hasContentIssue false
  • English
  • Français

Early stage biliary and intrahepatic migration of Opisthorchis viverrini in the golden hamster

Published online by Cambridge University Press:  01 March 2007

C. Nithikathkul ,
S. Tesana ,
P. Sithithaworn  and
S. Balakanich
C. Nithikathkul*
Affiliation:
Department of Biological Science, Faculty of Science and Technology, Huachiew Chalermprakiet University, Samut Prakan, 10540, Thailand: Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand
S. Tesana
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
P. Sithithaworn
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
S. Balakanich
Affiliation:
Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand
*
*Fax: 662-3126458 E-mail: choosak@hcu.ac.th
Get access Rights & Permissions [Opens in a new window]

Abstract

In Thailand, infection with the liver fluke Opisthorchis viverrini is a serious health problem, with over 8.6 million human infections each year. Early stage biliary intrahepatic migration and infection of O. viverrini in the Syrian golden hamster were used to study the growth and development of this fluke. Fifty metacercariae of O. viverrini were introduced into each hamster by gastric intubation. Worms were found to migrate rapidly from the stomach to the gall bladder and hepatic duct, where they remained in relatively constant numbers until the end of week 8. Sexual development of worms was rapid, with full development of the uterus and testes by one and one half weeks and the appearance of eggs in the uterus by the beginning of the third week of infection. Worm growth as indicated by body length had ceased by week 8. Hamsters demonstrated development of a full reproductive cycle with in three to four weeks, and this generation continued until 8 weeks.

Type
Research Papers
Information
Journal of Helminthology , Volume 81 , Issue 1 , March 2007 , pp. 39 - 41
Copyright
Copyright © 2007 Cambridge University Press 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Apinhasmit, W., Sobhon, P., Saitongdee, P. & Upatham, E.S. (1993) Opisthorchis viverrini: changes of the tegumental surface in newly excysted juvenile, first week and adult fluke. International Journal for Parasitology 23, 829–839.CrossRefGoogle Scholar
Flavell, D., Flavell, S.U. & Field, G.R. (1983) Opisthorchis viverrini: the relationship between egg production, worm size and intensity of infection in the hamster. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 538–545.CrossRefGoogle ScholarPubMed
Hong, S.T., Kho, W.G., Kim, W.H., Chai, J.Y. & Lee, S.H. (1993) Turnover of biliary epithelial cells in Clonorchis sinensis infected rats. Korean Journal of Parasitology 31, 83–89.CrossRefGoogle ScholarPubMed
Komiya, Y. (1966) Clonorchis and clonorchiasis. Advances in Parasitology 4, 53–106.CrossRefGoogle ScholarPubMed
Nithikathkul, C. (2000) Liver fluke. Journal of Communicable Diseases 26, 274–278.Google Scholar
Nithikathkul, C. & Puapairoj, A. (2002) Opisthorchiasis. Association of Private Higher Education Institutions of Thailand Journal 9, 49–53.Google Scholar
Sadun, E.H. (1955) Studies on Opisthorchis viverrini in Thailand. American Journal of Hygiene. 62, 81–115.Google ScholarPubMed
Sithithaworn, P., Tesana, S., Pipitgool, V., Kaekes, S., Thaiklor, K., Pairojkol, C., Sripa, B., Paupairoj, A., Sanpitak, P. & Aranyanat, C. (1991) Quantitative post-mortem study of Opisthorchis viverrini in man in northeast Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 756–758.CrossRefGoogle Scholar
Sripa, B. & Kaewkes, S. (2000) Localisation of parasite antigen and inflammatory responses in experimental opisthorchiasis. International Journal for Parasitology 30, 735–740.CrossRefGoogle ScholarPubMed
Tansurat, P. (1971) Opisthorchiasis in Thailand. pp. 535–545in Marcel-Rojas, P.A. (Ed.) Pathology of protozoal and helminthic diseases with clinical correlation. Baltimore, Williams and Wilkins.Google Scholar
Upatham, E.S., Brockelman, W.Y., Viyanant, V., Lee, P., Kaengraeng, R. & Prayoonwiwat, B. (1985) Incidence of endemic Opisthorchis viverrini infection in a village in northeast Thailand. American Journal of Tropical Medicine and Hygiene 34, 903–906.CrossRefGoogle Scholar