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Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis

Published online by Cambridge University Press:  12 April 2024

S. Wongkamchai ,
C. Rochjanawatsiriroj ,
N. Monkong ,
H. Nochot ,
S. Loymek ,
C. Jiraamornnimit ,
S. Hunnangkul  and
W. Choochote
S. Wongkamchai*
Affiliation:
Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Parnnok Road, Bangkok-Noi, Bangkok, Thailand
C. Rochjanawatsiriroj
Affiliation:
Bureau of Vector Borne Diseases, Ministry of Public Health, Nonthaburi Province, Thailand
N. Monkong
Affiliation:
Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Parnnok Road, Bangkok-Noi, Bangkok, Thailand
H. Nochot
Affiliation:
Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Parnnok Road, Bangkok-Noi, Bangkok, Thailand
S. Loymek
Affiliation:
Bureau of Vector Borne Diseases, Ministry of Public Health, Nonthaburi Province, Thailand
C. Jiraamornnimit
Affiliation:
Bureau of Vector Borne Diseases, Ministry of Public Health, Nonthaburi Province, Thailand
S. Hunnangkul
Affiliation:
Research and Development Centre, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
W. Choochote
Affiliation:
Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*
*Corresponding author: Fax: +66 02 4112084, Email: siswk@mahidol.ac.th
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Abstract

To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.

Type
Research Article
Information
Journal of Helminthology , Volume 80 , Issue 4 , December 2006 , pp. 363 - 367
Copyright
Copyright © Cambridge University Press 2006

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