Skip to main content Accessibility help

Cortisone-sensitive, innate resistance to Hymenolepis nana infection in congenitally athymic nude rats

  • Akira Ito (a1) and Tsuneo Kamiyama (a2)


The innate resistance of the unnatural rat host to the mouse tapeworm Hymenolepis nana is cortisone sensitive but thymus independent. When congenitally athymic nude rats were orally given eggs, cysticercoids, or adult worms of H. nana, no lumenal adults were established except when they were treated with cortisone acetate during the expected lumenal development. The effect of cortisone to promote adult maturation in the rats was compared in nude and normal rats given eggs of H. nana. The fecundity of the worm (assessed by the fresh worm biomass and the number of infective eggs produced) was much higher in cortisone-treated nude rats than in cotrisone-trated norml rats. When the nude rats recostituted with thymocytes were given eggs and treated with cortisone, the fecundity of H. nana dropped to the same level as in cortisone-treated normal rats. It is strongly suggested that the unnatural rat host has thymus-independent cortisone sensitive resistance to an intial infection (which is the main component of the innate resistance and blocks the lumenal establishment of this parasite) and thymus-dependent resistance (which suppresses the established worm' fecudity and may be ascribed to acquired resistance to the ongoing infection).



Hide All
Andreassen, J., Hindsbo, O. & Vienberg, S. (1982) Responsiveness of congenitally thymus deficient nude mice to the intestinal cestode, Hymenolepis diminuta. International Journal for Parasitology, 12, 215219.
Heyneman, D. (1962) Studies on helminth immunity: II. Influence of Hymenolepis nana (Cestoda: Hymenolepididae) in dual infection with H. diminuta in white mice and rats. Experimental Parasitology, 12, 718.
Ito, A. (1980) Hymenolepis nana: Survival in the immunized mouse. Experimental Parasitology, 49, 248257.
Ito, A. (1981) Comparison of the kinetics fo infection with Hymenolepis nana between BALB/c and dd strains of mice. Japanese Journal of Parasitology, 30, 439446.
Ito, A. (1982) Induction of adult formation from cysticercoid of Hymenolepis nana established in Fischer (F344) rat with cortisone acetate. Japanese journal of Parasitology, 31, 141146.
Ito, A. (1983) Hymenolepis nana: Maturation in an immunosuppressed unnatural rat host. Experimental Parasitology, 56, 318326.
Ito, A. (1985) Thymus dependency of the host resistance to infection with Hymenolepis nana (cestode) in the natural mouse and unnatural rat hosts. In: Genetic Control of Host Resistance to Infection and Malignancy (editor. Skamene, E.) pp. 471476. Alan R. Liss: New York.
Ito, A. & Kamiyama, T. (1984). Hymenolepis nana: Comparision of worm recovery between congenitally athymic nude and phenotypically normal rats and mice. Experimental Parasitology, 58, 132137.
Ito, A. & Smyth, J. D. (1987) Adult Cestodes. Immunology of the lumen-dwelling cestode infections. In: Immune Responses in Parasitic Infections: The Immunology, Immunopathology, and immunoprophylaxis (editor, Soulsby, E. J. L.) Vol. 2. CRC Press: Boca Raton. (in press).
Ito, A., Kano, S., Hioki, A., Kasuya, S. & Ohtomo, H. (1986) Reduced fecundity of Hymenolepis nana due to thymus-dependent immunological responses in mice. International Journal for Parasitology, 16, 8185.
Mitchell, G. F. (1979) Responses to infection with metazoan and protozoan parasites in mice. Advances in immunology, 28, 451511.
Mitchell, G. F. (1982) The nude mouse in immunoparasitology. In: The Nude Mouse in Experimental Clinical Research II (editors. Fogh, J. & Giovanella, B. C.) pp. 10211059.
Ogilvie, B. M. & Parrott, D. M. (1977) The immunological consequences of nematode infection. In: Immunology of the Gut (editors. Porter, R. & Knight, J.) pp. 183201. Elsevier: Amsterdam.
Rose, M. E., Ogilvie, B. M., Hesketh, P. & Festing, M. F. W. (1979) Failure of nude (athymic) rats to become resistant to reinfeciton with the interstinal coccidian parasiste Eimeria nieschulzi or the nematode Nippostrongylus brasiliensis. Parasite Immunology, 1, 125132.
Shorb, D. A. (1933) Host-parasite relations of Hymenolepis fraterna in the rat and mouse. American Journal of Hygiene, 18, 74113.
Stevens, D. P., Frank, D. M. & Mahmoud, A. A. F. (1978) Thymus dependency of host resistance to Giradia muris infection: Studies in nude mice. Journal of Immunology, 120, 680682.
Wakelin, D. (1978) Immunity to intestinal parasites. Nature. 273, 617620.
Weinmann, C. J. (1964) Host resistance to Hymenolepis nana. II. Specificity of resistance to reinfection in th direct cycle. Experimental Parasitology. 15, 514526.


Related content

Powered by UNSILO

Cortisone-sensitive, innate resistance to Hymenolepis nana infection in congenitally athymic nude rats

  • Akira Ito (a1) and Tsuneo Kamiyama (a2)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.