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Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature Hymenolepis nana in mice

Published online by Cambridge University Press:  18 November 2009

Jun Maki  and
Toshio Yanagisawa
Jun Maki
Affiliation:
Department of Parasitology, KitasatoUniversity School of Medicine, Sagamihara, 228 Japan
Toshio Yanagisawa
Affiliation:
Department of Parasitology, KitasatoUniversity School of Medicine, Sagamihara, 228 Japan
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Abstract

The anthelmintic effects of anti-tapeworm drugs, bithionol, paromomycin sulphate, flubendazole and mebendazole on immature and mature Hymenolepis nana in mice were compared. Immature worms were not affected by paromomycin sulphate or flubendazole administered for 12 consecutive days (days one to 12 after infection) at lOOmg/kg/day but 48% and 100% of H. nana were eliminated from mice by bithionol and mebendazole respectively, at the same dosage regimen. Bithionol, paromomycin sulphate, flubendazole and mebendazole given at 100 mg/kg/day for five consecutive days (days 12 to 16 after infection) eliminated 32%, 29%, 36% and 100% of mature worms respectively. 10 and 20 mg of mebendazole/kg/day for five consecutive days (days 12 to 16 after infection) had little effect on mature worms whereas 50 and 100 mg/kg/day for the same period eliminated 99% and 100% of mature worms, respectively. ED50 of mebendazole in the elimination of mature H. nana was 14 or 15 mg/kg/day for five days from the reduction in dry weight or in number of worms recovered respectively. The effects of mebendazole given 2 to 4 days, 8 to 10 days or 13 to 15 days after infection at lOOmg/kg/day were compared. Very low, if any, activity of the drug given 2 to 4 days after infection was seen, whereas the drug given 8 to 10 days or 13 to 15 days after infection eliminated 84% and 86% of H. nana respectively.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 3 , September 1985 , pp. 211 - 216
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Botero, D. R. (1970) Paromomycin as effective treatment of Taenia infections. American Journal of Tropical Medicine and Hygiene, 19, 234–237.CrossRefGoogle ScholarPubMed
Brugmans, J. P., Thienpont, D. C., Van Wijngaarden, I., Vanparijs, O. F., Schuermans, V. L. & Lauwers, H. L. (1971) Mebendazole in enterobiasis, Radiochemical and pilot clinical study in 1278 subjects. Journal of the American Medical Association, 217, 313–316.CrossRefGoogle Scholar
Higaki, K., Takahashi, N., Noguchi, Y. & Kowa, Y. (1963) Studies on chemotherapy of paragonimiasis I. Comparison of bis-(2-hydroxy-3, 5-dichlorophenyl)-sulfoxide (BTS) and 2, 2′-thiobis (4, 6-dichlophenol) (BT) on anthelmintic effect of the rats infected with Paragonimus iloktsuenensis and their pharmacological effects. Japanese Journal of Parasitology, 12, 226–234.Google Scholar
Imai, S., Noguchi, K., Sasaki, Y., Saeki, H., Hiyama, M. & Ishii, T. (1981) Light and scanning electron microscopical examination on the effects of paromomycin sulfate to Hymenolepis nana (Cestoda) in vitro. Japanese Journal of Parasitology, 30, 397–404.Google Scholar
Kagei, N. & Hayashi, S. (1979) [Aminosidine as an anti-tapeworm drug.] Shinryo to Shinyaku, 16, 2807–2817. ‘In Japanese.’Google Scholar
Maki, J., Kondo, A. & Yanagisawa, T. (1983) Effects of alcoholic extract from Ma-Klua (Diospyros mollis) on adults and larvae of the dwarf tapeworm, Hymenolepis nana in mice and on the infectivity of the eggs. Parasitology, 87, 103–111.CrossRefGoogle ScholarPubMed
Maki, J. & Yanagisawa, T. (1983) A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice. Parasitology, 87, 525–531.CrossRefGoogle ScholarPubMed
Marsboom, R. (1973) Toxicologic studies on mebendazole. Toxicology and Applied Pharmacology, 24, 371–377.CrossRefGoogle ScholarPubMed
Nagahana, M., Yoshida, Y., Matsuno, K. & Kondo, K. (1966) Treatment of Taenia saginata and Diphyllobothrium latum infections with bithionol. American Journal of Tropical Medicine and Hygiene, 15, 351–354.CrossRefGoogle ScholarPubMed
Nagaty, H. F., Rifaat, M. A. & Salem, S. (1962) Clinical trial with Yomesan in Hymenolepis nana infection. Journal of Tropical Medicine and Hygiene, 65, 128–129.Google Scholar
Novak, M. & Evans, W. S. (1981) Mebendazole and the development of Hymenolepis nana in mice. International Journal for Parasitology, 11, 277–280.CrossRefGoogle ScholarPubMed
Salem, H. H. & El-Allaf, G. (1969) Treatment of Taenia saginata and Hymenolepis nana infections with paromomycin. Transactions of the Royal Society of Tropical Medicine and Hygiene, 63, 833–836.CrossRefGoogle ScholarPubMed
Schenone, H. (1980) Praziquantel in the treatment of Hymenolepis nana infections in children. American Journal of Tropical Medicine and Hygiene, 29, 320–321.CrossRefGoogle ScholarPubMed
Schenone, H., Galdames, M. & Cabello, C. (1975) Tratamiento de las helmintiasis intestinales humanas con una asociacion de mebendazol y tiabendazol. Boletin Chileno de Parasitologia, 30, 89–90.Google Scholar
Seo, B. S., Cho, S. Y., Kang, S. Y. & Chai, J. Y. (1977) Anthelmintic efficacy of methyl-5-benzoyl benzimidazole-2-carbamate (Mebendazole) against multiple helminthic infections. Korean Journal of Parasitology, 15, 11–16.CrossRefGoogle ScholarPubMed
TellÉz-girÓn, E., Ramos, M. C. & Montante, M. (1981) Effects of flubendazole on Cysticercus cellulosae in pigs. American Journal of Tropical Medicine and Hygiene, 30, 135–138.CrossRefGoogle ScholarPubMed
Thienpont, D., Vanparijs, O., Niemegeers, C. & Marsboom, R. (1978) Biological and pharmacological properties of flubendazole. Arzneimittel-Forschung, 28 (1), 605–612.Google ScholarPubMed
Thomas, H. & GÖnnert, R. (1977) The efficacy of praziquantel against cestodes in animals. Zeitschrift für Parasitenkunde, 52, 117–127.CrossRefGoogle ScholarPubMed
Van Den Bossche, H. (1982) Present state of mebendazole and flubendazole. In: Parasites-Their World and Ours (editors Mettrick, D. F. & Desser, S. S.), pp. 336–339. Elsevier Biomedical Press: Amsterdam.Google Scholar
Waitz, J. A., Mcclay, P. & Thompson, P. E. (1966) Effects of paromomycin on tapeworms of mice, rats and cats. Journal of Parasitology, 52, 830–831.CrossRefGoogle Scholar
Wilson, J. F., Davidson, M. & Rausch, R. L. (1978) A clinical trial of mebendazole in the treatment of alveolar hydatid disease. American Review of Respiratory Disease, 118, 747–757.CrossRefGoogle ScholarPubMed
Wittner, M. & Tanowitz, H. (1971) Paromomycin therapy of human cestodiasis with special reference to hymenolepiasis. American Journal of Tropical Medicine and Hygiene, 20, 433–435.CrossRefGoogle ScholarPubMed
Yokogawa, M., Yoshimura, H., Okura, T. & Saito, M. (1962) Effect of bithionol on a Taenia saginata, especially with reference to the detection of eggs with fecal examination and the perianal cellophane tape method. Journal ofChiba Medical Society, 37, 455–462.Google Scholar