Hostname: page-component-84b7d79bbc-tsvsl Total loading time: 0 Render date: 2024-07-28T10:07:15.670Z Has data issue: false hasContentIssue false
  • English
  • Français

Observations on the gross changes in the secondary lymphoid organs of mice infected with Nematospiroides dubius

Published online by Cambridge University Press:  18 November 2009

Najah M. H. Ali  and
Jerzy M. Behnke
Najah M. H. Ali
Affiliation:
Experimental Parasitology Unit, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Jerzy M. Behnke
Affiliation:
Experimental Parasitology Unit, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Get access Rights & Permissions [Opens in a new window]

Abstract

Gross changes in the size of the secondary lymphoid organs were studied during infection with the nematode parasite Nematospiroides dubius. In the strong responder NIH strain, the wet weight of the mesenteric lymph nodes (MLN) increased rapidly following infection with 400 larvae to peak on day 28 at approximately three times the resting weight. Enlargement of the spleens was also marked but regression to normal size took place when the MLN had achieved maximum size. In contrast in C57BL/10 mice, a slow responder strain, the enlargement of the MLN following infection was relatively slow, and there was no evidence of the regression of the spleen, once maximum enlargement had been achieved.

When adult worms were removed by anthclmintic, the enlarged MLN and spleens returned rapidly to normal size. I lowever, in mice infected with irradiated larvae (25 krad) the MLN stayed enlarged, despite the absence of adult worms but the spleens of these mice returned to normal size fairly rapidly. It was suggested that irradiated worms survive, perhaps as arrested larvae in the intestinal tissue, for a fairly long time, thereby providing a continual stimulus for the MLN.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 2 , June 1985 , pp. 167 - 174
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Ali, N. M. H. (1983) The effect of infection with Nematospiroides dubius on the immune responsiveness of mice. Ph.D. Thesis, University of Nottingham.Google Scholar
Ali, N. M. H., Behnke, J. M. & Manger, B. R. (1985) The pattern of peripheral blood leucocyte changes in mice infected with Nematospiroldes duhius. Journal of Helminthology, 59, 83–93.CrossRefGoogle Scholar
Baker, N. F. (1962) The nature and etiology of the lcucocytic response of Webster mice infected with Nematospiroides duhius. Journal of Parasitology, 48, 438–441.CrossRefGoogle Scholar
Behnke, J. M. & Parish, H. A. (1979) Nematospiroides duhius: arrested development of larvae in immune mice. Experimental Parasitology, 47, 116–127.CrossRefGoogle Scholar
BEHNKE, J. M., PARISH, II. A. & Hagan, P. (1980) The effect of gamma irradiation on Nematospiroides dubius: factors affecting the survival of worms in a primary infection in mice. Journal of Helminthology, 54, 173–182.CrossRefGoogle Scholar
Behnke, J. M. & Wakelin, D. (1977) Nematospiroldes dubius: stimulation of acquired immunity in inbred strains of mice. Journal of Helminthology, 51, 167–176.CrossRefGoogle Scholar
Cypess, R. (1972) Blood cell count changes associated with immunity to Nematospiroldes dublus. Journal of Parasitology, 58, 563–566.CrossRefGoogle Scholar
Dobson, C. (1982) Passive transfer of immunity with scrum in mice infected with Nematospiroides dubius: influence of quality and quantity of immune scrum. International Journal for Parasitology, 12, 207–213.CrossRefGoogle Scholar
Dobson, C. & Cayzer, J. R. (1982) immunosuppressive activity in scrum from mice infected with Nematospiroides dubius following passive scrum transfer. International Journal for Parasitology, 12, 561–566.CrossRefGoogle Scholar
Ehrenford, F. A. (1954) The life cycle of Nematospiroldes dubius Baylis (Nematoda: Heligmosomidae). Journal of Parasitology, 40, 480–481.CrossRefGoogle Scholar
Hagan, P., Behnke, J. M. & Parish, A. (1981) Stimulation of immunity to Nematospiroides dubius in mice using larvae attenuated by cobalt 60 irradiation. Parasite Immunology, 3, 149–156.CrossRefGoogle Scholar
Humphery, J. H. & White, R. G. (1971) Immunology for Students of Medicine, Third Edition. Blackwell Scientific Publications, Oxford and Edinburgh, UK.Google Scholar
Jenkins, S. N. & Behnke, J. M. (1977) Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology, 75, 71–78.CrossRefGoogle Scholar
Liu, S. K. (1965) Pathology of Nematospiroides dubius. 1. Primary infections in C311 and Webster mice. Experimental Parasitology, 17, 123–135.CrossRefGoogle Scholar
Price, P. & Turner, K. J. (1983) Immunological consequences of intestinal helminth infections in C57BL mice. The effects on lymphoid tissue and rcticulocndothclial function. Australian Journal of Experimental Biology and Medical Science, 61, 371–382.CrossRefGoogle Scholar
Pritchard, D. I., Behnke, J. M. & Williams, D. J. L. (1983) Primary infection sera and IgG1 do not block host-protective immunity to Nematospiroides dubius. Immunology, 51, 73–81.Google Scholar
Sokal, R. R. & Rohlf, F. J. (1969) Biometry. Freeman, San Francisco.Google Scholar
Williams, D. J. L. (1982) Analysis of the immune response to Nematospiroides dubius in the mouse. Ph.D. Thesis, University of Nottingham.Google Scholar