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Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis

Published online by Cambridge University Press:  01 March 2007

P.C. Shih ,
H.H. Lee ,
S.C. Lai ,
K.M. Chen ,
S.T. Jiang ,
Y.F. Chen  and
S.J. Shiow
P.C. Shih
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
H.H. Lee
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.C. Lai
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
K.M. Chen
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.T. Jiang
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
Y.F. Chen
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.J. Shiow*
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
*
*Author for correspondence Fax: (886) 4 23823381 E-mail: shih@csmu.edu.tw
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Abstract

Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or eosinophilic meningoencephalitis. Curcumin is a natural product which has the effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while the administration of curcumin has been reported to possibly relieve the symptoms of meningitis. The present study tested the potential efficacy of curcumin in A. cantonensis-induced eosinophilic meningitis of BALB/c mice. Assay indicators for the therapeutic effect included the larvicidal effect, eosinophil counts and matrix metalloproteinase-9 (MMP-9) activity in angiostrongyliasis. Eosinophils were mildly reduced in treatment groups compared with infected-untreated mice. However, there were no significant differences in larvicidal effects or MMP-9 activity. This study suggests that anti-inflammatory treatment with curcumin alone has low efficacy, but the treatment does not interfere with MMP-9 expression and is not useful for larvicidal effects. The possible reasons include low curcumin across the blood–brain barrier and also those larvae that survive stimulate MMP-9 production, which promotes blood–brain barrier damage, with leukocytes then crossing the blood–brain barrier to cause meningitis. Further studies will be required to test these possibilities.

Type
Research Papers
Information
Journal of Helminthology , Volume 81 , Issue 1 , March 2007 , pp. 1 - 5
Copyright
Copyright © 2007 Cambridge University Press 2007

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References

Ammon, H.P. & Wahl, M.A. (1991) Pharmacology of Curcuma longa. Planta Medica 57, 1–7.CrossRefGoogle ScholarPubMed
Ash, L.R. (1970) Diagnostic morphology of the third-stage larvae of Angiostrongylus cantonensis, Angiostrongylus vasorum, Aelurostrongylus abstrusus, and Anafilaroides rostratus (Nematoda: Metastrongyloidea). Journal of Parasitology 56, 249–253.CrossRefGoogle ScholarPubMed
Dell'Albani, P., Santangelo, R., Torrisi, L., Nicoletti, V.G., Vellis, J. & Giuffrida Stella, A.M. (2001) JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. Journal of Neuroscience Research 65, 417–424.CrossRefGoogle ScholarPubMed
Hackett, R.H., Wang, Y.D., Sweitzer, S., Feldman, G., Wood, W.I. & Larner, A.C. (1997) Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins. Journal of Biological Chemistry 272, 11128–11132.CrossRefGoogle ScholarPubMed
Kelloff, G.J., Crowell, J.A., Steele, V.E., Lubet, R.A., Malone, W.A., Boone, C.W., Kopelovich, L., Hawk, E.T., Lieberman, R., Lawrence, J.A., Ali, I., Viner, J.L. & Sigman, C.C. (2000) Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. Journal of Nutrition 130, 467S–471S.CrossRefGoogle ScholarPubMed
Kim, H.Y., Park, E.J., Joe, E.H. & Jou, I. (2003) Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. Journal of Immunology 171, 6072–6079.CrossRefGoogle ScholarPubMed
Lai, S.C., Twu, J.J., Jiang, S.T., Hsu, J.D., Chen, K.M., Chiaing, H.C., Wang, C.J., Tseng, C.K., Shyu, L.Y. & Lee, H.H. (2004) Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. Annals of Tropical Medicine and Parasitology 98, 715–724.CrossRefGoogle ScholarPubMed
Lan, K.P., Wang, C.J., Hsu, J.D., Chen, K.M., Lai, S.C. & Lee, H.H. (2004a) Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-κB and MEKK1/JNK signals. Journal of Helminthology 78, 311–317.CrossRefGoogle ScholarPubMed
Lan, K.P., Wang, C.J., Lai, S.C., Chen, K.M., Lee, S.S., Hsu, J.D. & Lee, H.H. (2004b) The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitology Research 93, 311–317.CrossRefGoogle ScholarPubMed
Lee, H.H., Chou, H.L., Chen, K.M. & Lai, S.C. (2004) Association of matrix-metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitology Research 94, 321–328.CrossRefGoogle ScholarPubMed
Leppert, D., Leib, S.L., Grygar, C., Miller, K.M., Schaad, U.B. & Holländer, G.A. (2000) Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clinical Infectious Diseases 31, 80–84.CrossRefGoogle ScholarPubMed
Lindo, J.F., Waugh, C., Hall, J., Cunningham-Myrie, C., Ashley, D., Eberhard, M.L., Sullivan, J.J., Bishop, H.S., Robinson, D.G., Holtz, T. & Robinson, R.D. (2002) Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. Emerging Infectious Diseases 8, 324–326.CrossRefGoogle ScholarPubMed
Parsons, J.C. & Grieve, R.B. (1990) Effect of egg dosage and host genotype on liver trapping in murine larval toxocariasis. Journal of Parasitology 76, 53–58.CrossRefGoogle ScholarPubMed
Paul, R., Lorenzl, S., Koedel, U., Sporer, B., Vogel, U., Frosch, M. & Pfister, H.W. (1998) Matrix metalloproteinases contribute to the blood–brain barrier disruption during bacterial meningitis. Annals of Neurology 44, 592–600.CrossRefGoogle Scholar
Rane, S.G. & Reddy, E.P. (2000) Janus kinases: components of multiple signaling pathways. Oncogene 19, 5662–5679.CrossRefGoogle ScholarPubMed
Romanic, A.M. & Madri, J.A. (1994) Extracellular matrix-degrading proteinases in the nervous system. Brain Pathology 4, 145–156.CrossRefGoogle ScholarPubMed
Rosenberg, G.A., Kornfeld, M., Estrada, M., Kelley, R.O., Liotta, L.A. & Stetler-Stevenson, W.G. (1992) TIMP-2 reduces proteolytic opening of blood–brain barrier by type-IV collagenase. Brain 576, 203–207.Google ScholarPubMed
Ruby, A.J., Kuttan, G., Babu, K.D., Rajasekharan, K.N. & Kuttan, R. (1995) Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters 94, 79–83.CrossRefGoogle ScholarPubMed
Srimal, R.C. & Dhawan, B.N. (1973) Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. Journal de Pharmacologie 25, 447–452.Google ScholarPubMed
Surh, Y.J. (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food and Chemical Toxicology 40, 1091–1097.CrossRefGoogle ScholarPubMed
Toda, S., Miyase, T., Arichi, H., Tanizawa, H. & Takino, Y. (1985) Natural antioxidants III. Antioxidative components isolated from rhizome of Curcuma longa L. Chemical and Pharmaceutical Bulletin 33, 1725–1728.CrossRefGoogle ScholarPubMed