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Abnormal development of Hymenolepis nana larvae in immunosuppressed mice

Published online by Cambridge University Press:  05 June 2009

S. B. Lucas ,
O. Hassounah ,
R. Muller  and
M. J. Doenhoff
S. B. Lucas
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
O. Hassounah
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
R. Muller
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
M. J. Doenhoff
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, England
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Abstract

Observations on the course of Hymenolepis nana infection in immunosuppressed mice are presented. Treatment of the host with hydrocortisone acetate caused superinfection of the bowel with worms and the development of normal cysticercoids in the mesenteric lymph node and liver. Natural infection of mice deprived of their T-cells by pre-adult thymectomy and administration of antithymocyte serum resulted in superinfection and widespread metastasis of aberrant cysticercoids that were greatly enlarged and without scolices, causing death after about five months. The significance of these findings and their possible relevance to human infection with H. nana are discussed.

Type
Research Papers
Information
Journal of Helminthology , Volume 54 , Issue 2 , June 1980 , pp. 75 - 82
Copyright
Copyright © Cambridge University Press 1980

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