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Size for gestational age at birth according to offspring sex and gestational weight gain in underweight women

  • Y. Kasuga (a1), D. Shigemi (a2), M. Tamagawa (a1), T. Suzuki (a1), S.-H. Kim (a1), T. Higuchi (a1), H. Yasunaga (a2) and S. Nakada (a1)...

Abstract

Although maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are related to fetal growth, there is a paucity of data regarding how offspring sex affects the relationship between maternal BMI in underweight mothers (pre-pregnancy BMI <18.5 kg/m2) and size for gestational age at birth. The aim of this study was to investigate the effect of offspring sex on the relationships among maternal pre-pregnancy BMI, GWG and size for gestational age at birth in Japanese underweight mothers. Records of women with full-term pregnancies who underwent perinatal care at Kawasaki Municipal Hospital (Kawasaki, Japan) between January 2013 and December 2017 were retrospectively reviewed. The study cohort included underweight (n=566) and normal-weight women (18.5 kg/m2⩽pre-pregnancy BMI<25 kg/m2; n=2671). The incidence of small for gestational age (SGA) births in the underweight group was significantly higher than that in the normal-weight group (P<0.01). Additionally, SGA incidence in the underweight group was significantly higher than that in the normal-weight group (P<0.01) in female, but not male (P=0.30) neonates. In the women with female neonates, pre-pregnancy underweight was associated with a significantly increased probability of SGA (odds ratio [OR]: 1.80; P<0.01), but inadequate GWG was not (OR: 1.38; P=0.11). In contrast, in women with male neonates, inadequate GWG was associated with a significantly increased probability of SGA (OR: 1.53; P=0.03), but not with pre-pregnancy underweight (OR: 1.30; P=0.10). In conclusion, the present results suggest that pre-pregnancy underweight is associated with SGA in female offspring but not in male offspring.

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Corresponding author

*Address for correspondence: Y. Kasuga, Department of Obstetrics and Gynecology, Kawasaki Municipal Kawasaki Hospital, 12-1 Shinkawa-Dori, Kawasaki-ku, Kawasaki, Kanagawa 210-0013, Japan. E-mail: 17yoshi23.k@gmail.com

References

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Journal of Developmental Origins of Health and Disease
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  • EISSN: 2040-1752
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