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Poor perinatal growth impairs baboon aortic windkessel function

  • A. H. Kuo (a1), J. Li (a2) (a3), C. Li (a4) (a3), H. F. Huber (a4), P. W. Nathanielsz (a4) (a3) and G. D. Clarke (a1) (a3)...

Abstract

The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10−3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.

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Corresponding author

*Address for correspondence: A. H. Kuo, MD, Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7800, San Antonio, TX 78229-3900, USA. (Email kuoa@uthscsa.edu)

References

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Keywords

Poor perinatal growth impairs baboon aortic windkessel function

  • A. H. Kuo (a1), J. Li (a2) (a3), C. Li (a4) (a3), H. F. Huber (a4), P. W. Nathanielsz (a4) (a3) and G. D. Clarke (a1) (a3)...

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