Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-25T05:52:07.069Z Has data issue: false hasContentIssue false
  • English
  • Français

Neonatal fatty acid profiles are correlated with infant growth measures at 6 months

Published online by Cambridge University Press:  16 March 2017

P. F. O’Tierney-Ginn ,
D. Davina ,
M. Gillingham ,
D. J. P. Barker ,
C. Morris  and
K. L. Thornburg
P. F. O’Tierney-Ginn*
Affiliation:
Department of Reproductive Biology, Center for Reproductive Health, Case Western Reserve University, Cleveland, OH, USA
D. Davina
Affiliation:
Peachtree Healthcare, Sacramento, CA, USA
M. Gillingham
Affiliation:
Department of Molecular & Medical Genetics, Oregon Health and Science University (OHSU), Portland, OR, USA
D. J. P. Barker
Affiliation:
Center for Developmental Health, OHSU Knight Cardiovascular Institute Bob and Charlee Moore Institute for Nutrition and Wellness, OHSU, OR, USA
C. Morris
Affiliation:
Department of Med Informatics & Clinical Epidemiology, OHSU, OR, USA
K. L. Thornburg
Affiliation:
Center for Developmental Health, OHSU Knight Cardiovascular Institute Bob and Charlee Moore Institute for Nutrition and Wellness, OHSU, OR, USA
*
*Address for correspondence: Perrie O’Tierney-Ginn, PhD, 2500 MetroHealth Drive, R358 Cleveland, OH 44118, USA. (Email poginn@metrohealth.org)
Get access Rights & Permissions [Opens in a new window]

Abstract

Rapid weight gain in infancy and low levels of n-3 long chain polyunsaturated fatty acids (LCPUFA) at birth are associated with increased adiposity later in life. The association between placental LCPUFA delivery and weight gain in infancy is poorly understood. We sought to determine the relationships between maternal phenotype, placental fatty acid transporter expression and offspring growth patterns over the first 6 months. Placental tissue and cord blood were collected at term delivery from women with uncomplicated pregnancies. Offspring body composition measurements were recorded 1 day and 6 months after birth. Body mass index (BMI) z-scores were determined using World Health Organization 2006 reference data. Body phenotype patterns were compared among offspring who had an increase in BMI z-score and those who had a decrease. High skinfold thickness at birth and positive change in BMI z-scores during infancy were associated with low neonatal n-3 LCPUFA plasma levels (r=−0.46, P=0.046) and high saturated fatty acids levels (r=0.49, P=0.034). Growth of skinfolds over 6 months of age was associated with placental fatty acid transporter gene expression. Change in BMI z-score in the first 6 months of life correlated with arm muscle area growth, a measure of lean mass (r=0.62, P=0.003), but not with growth in skinfold thickness. Early infancy weight gain was associated with poor plasma LCPUFA status at birth, and fat deposition in infancy was related to changes in placental lipid handling. Thus, neonatal fatty acid profiles may influence the trajectory of infant growth and fat and lean mass deposition.

Keywords

adiposityfatty acidsinfant growthplacenta
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 4: Themed Issue: Assisted Reproductive Treatments (ART) and DOHAD , August 2017 , pp. 474 - 482
Check for updates
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

✠

Deceased.

References

1. Ogden, CL, Carroll, MD, Kit, BK, Flegal, KM. Prevalence of childhood and adult obesity in the united states, 2011–2012. JAMA. 2014; 311, 806–814.Google Scholar
2. Taveras, EM, Rifas-Shiman, SL, Belfort, MB, et al. Weight status in the first 6 months of life and obesity at 3 years of age. Pediatrics. 2009; 123, 1177–1183.Google Scholar
3. Baird, J, Fisher, D, Lucas, P, et al. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ. 2005; 331, 929.CrossRefGoogle ScholarPubMed
4. Ong, KK, Loos, RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 2006; 95, 904–908.CrossRefGoogle ScholarPubMed
5. Monteiro, PO, Victora, CG. Rapid growth in infancy and childhood and obesity in later life – a systematic review. Obesity Rev. 2005; 6, 143–154.CrossRefGoogle ScholarPubMed
6. Leunissen, RW, Kerkhof, GF, Stijnen, T, Hokken-Koelega, A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA. 2009; 301, 2234–2242.Google Scholar
7. Belfort, MB, Rifas-Shiman, SL, Rich-Edwards, J, Kleinman, KP, Gillman, MW. Size at birth, infant growth, and blood pressure at three years of age. J Pediatr. 2007; 151, 670–674.CrossRefGoogle ScholarPubMed
8. Donahue, SM, Rifas-Shiman, SL, Gold, DR, et al. Prenatal fatty acid status and child adiposity at age 3 y: results from a us pregnancy cohort. Am J Clin Nutr. 2011; 93, 780–788.Google Scholar
9. Hauner, H, Much, D, Vollhardt, C, et al. Effect of reducing the n-6:N-3 long-chain pufa ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr. 2012; 95, 383–394.CrossRefGoogle ScholarPubMed
10. Salem, N Jr., Wegher, B, Mena, P, Uauy, R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci USA. 1996; 93, 49–54.Google Scholar
11. O’Tierney, PF, Lewis, RM, McWeeney, SK, et al. Immune response gene profiles in the term placenta depend upon maternal muscle mass. Reprod Sci. 2012; 19, 1041–1056.CrossRefGoogle ScholarPubMed
12. Lagerstedt, SA, Hinrichs, DR, Batt, SM, et al. Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders. Mol Genet Metab. 2001; 73, 38–45.Google Scholar
13. O’Tierney-Ginn, P, Roberts, V, Gillingham, M, et al. Influence of high fat diet and resveratrol supplementation on placental fatty acid uptake in the Japanese macaque. Placenta. 2015; 36, 903–910.CrossRefGoogle ScholarPubMed
14. Koontz, MB, Gunzler, DD, Presley, L, Catalano, PM. Longitudinal changes in infant body composition: association with childhood obesity. Pediatr Obesity. 2014; 9, e141–e144.CrossRefGoogle ScholarPubMed
15. Holzhauer, S, Hokken Koelega, AC, Ridder, M, et al. Effect of birth weight and postnatal weight gain on body composition in early infancy: The Generation R Study. Early Hum Dev. 2009; 85, 285–290.Google Scholar
16. Andres, A, Hull, HR, Shankar, K, et al. Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity. Obesity. 2015; 23, 1252–1258.CrossRefGoogle ScholarPubMed
17. Brunner, S, Schmid, D, Huttinger, K, et al. Effect of reducing the n-6/n-3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition. Obesity. 2014; 22, 217–224.CrossRefGoogle ScholarPubMed
18. Chandler-Laney, PC, Gower, BA, Fields, DA. Gestational and early life influences on infant body composition at 1 year. Obesity. 2013; 21, 144–148.CrossRefGoogle ScholarPubMed
19. Baker, J, Workman, M, Bedrick, E, et al. Brains versus brawn: an empirical test of Barker’s brain sparing model. Am J Hum Biol. 2010; 22, 206–215.Google Scholar
20. Rowe, RW, Goldspink, G. Muscle fibre growth in five different muscles in both sexes of mice. J Anat. 1969; 104, 519–530.Google ScholarPubMed
21. Joglekar, CV, Fall, CH, Deshpande, VU, et al. Newborn size, infant and childhood growth, and body composition and cardiovascular disease risk factors at the age of 6 years: The Pune Maternal Nutrition Study. Int J Obesity. 2007; 31, 1534–1544.Google Scholar
22. Eriksson, JG, Forsen, T, Tuomilehto, J, et al. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999; 318, 427–431.CrossRefGoogle ScholarPubMed
23. Xu, Y, Agrawal, S, Cook, TJ, Knipp, GT. Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. Placenta. 2008; 29, 962–969.Google Scholar
24. Dube, E, Gravel, A, Martin, C, et al. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. Biol Reprod. 2012; 87, 1–11, 14.Google Scholar
25. Brass, E, Hanson, E, O’Tierney-Ginn, PF. Placental oleic acid uptake is lower in male offspring of obese women. Placenta. 2013; 34, 503–509.Google Scholar
26. Larque, E, Krauss-Etschmann, S, Campoy, C, et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr. 2006; 84, 853–861.Google Scholar
27. Duttaroy, AK. Transport of fatty acids across the human placenta: a review. Prog Lipid Res. 2009; 48, 52–61.CrossRefGoogle ScholarPubMed
28. Yan, J, Liu, L, Zhu, Y, Huang, G, Wang, PP. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health. 2014; 14, 1267.Google Scholar
29. O’Tierney, PF, Barker, DJ, Osmond, C, Kajantie, E, Eriksson, JG. Duration of breast-feeding and adiposity in adult life. J Nutr. 2009; 139, 422s–425s.Google Scholar
Supplementary material: File

O’Tierney-Ginn supplementary material

Table S1

Download O’Tierney-Ginn supplementary material(File)
File 13 KB
Supplementary material: File

O’Tierney-Ginn supplementary material

Table S2

Download O’Tierney-Ginn supplementary material(File)
File 15.4 KB