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Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

  • S. Lecoutre (a1), L. Marousez (a1), A. Drougard (a2), C. Knauf (a2), C. Guinez (a1), D. Eberlé (a1), C. Laborie (a1), D. Vieau (a1), J. Lesage (a1) and C. Breton (a1)...


Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality. We investigated whether apelin and its receptor APJ could be a target of maternal undernutrition. Adult male rat offspring from FR30 dams showed increased plasma apelin levels and apelin gene expression in WAT. Post-weaning high-fat diet led to marked increase in APJ mRNA and protein levels in offspring’s WAT. We demonstrate that maternal undernutrition and post-weaning diet have long-term consequences on the apelinergic system of adult male rat offspring.


Corresponding author

*Address for correspondence: C. Breton, EA4489, Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Univ. Lille, F59000 Lille, France. (Email


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Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring

  • S. Lecoutre (a1), L. Marousez (a1), A. Drougard (a2), C. Knauf (a2), C. Guinez (a1), D. Eberlé (a1), C. Laborie (a1), D. Vieau (a1), J. Lesage (a1) and C. Breton (a1)...


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