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Female ponderal index at birth and idiopathic infertility

  • Charlotte Dupont (a1), Audrey Hulot (a2) (a3) (a4), Florence Jaffrezic (a2), Céline Faure (a5), Sébastien Czernichow (a6) (a7), Nathalie di Clemente (a8) (a9), Chrystele Racine (a8) (a9) (a10), Pascale Chavatte-Palmer (a11), Rachel Lévy (a1) and Alifert group...

Abstract

Epidemiological studies have demonstrated an increased risk of developing non-transmittable diseases in adults subjected to adverse early developmental conditions. Metabolic and cardiovascular diseases have been the focus of most studies. Nevertheless, data from animal models also suggest early programming of fertility. In humans, it is difficult to assess the impact of the in utero environment retrospectively. Birthweight is commonly used as an indirect indicator of intrauterine development. This research is part of the ALIFERT study. We investigated a potential link between ponderal index at birth and female fertility in adulthood. Data from 51 infertile and 74 fertile women were analysed. BW was on average higher in infertile women, whereas birth length did not differ between the two groups; thus, resulting in a significantly higher ponderal index at birth in infertile women. Ponderal index at birth has been identified as a risk factor for infertility. These results suggest the importance of the intra-uterine environment, not only for long-term metabolic health but also for fertility.

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Corresponding author

Address for correspondence: Charlotte Dupont, Saint Antoine Research center, INSERM équipe Lipodystrophies génétiques et acquises, Sorbonne Université and Service de biologie de la reproduction-CECOS, AP-HP, Hôpital Tenon, F-75020 Paris, France. Email: charlotte.dupont@aphp.fr

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Alifert Collaborative Group: Isabelle Aknin: Unité fonctionnelle de biologie de la reproduction, histologie – embryologie – cytogénétique, hôpital Nord, Saint-Étienne, France ; Isabelle Cedrin-Durnerin: Service de Médecine de la Reproduction, Hôpital Jean Verdier, APHP, Bondy, France ; Steven Cens, Centre d’AMP de PAU, Polyclinique de Navarre, Pau, France; Serge Hercberg: EREN, INSERM U557; INRA; CNAM; Université Paris 13, CRNH IdF, 93017 Bobigny, France; Khaled Pocate: Service d’Histologie-Embryologie-Biologie de la Reproduction, Hôpital Cochin APHP, Paris, France; Nathalie Sermondade: Service de biologie de la reproduction-CECOS, Hôpital Tenon, APHP, Paris, France ; Claude Uthurriague, Centre d’AMP de PAU, Polyclinique de Navarre, Pau ; Jean-Philippe Wolf: Service d’Histologie-Embryologie-Biologie de la Reproduction, Hôpital Cochin, APHP, Paris, France

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Female ponderal index at birth and idiopathic infertility

  • Charlotte Dupont (a1), Audrey Hulot (a2) (a3) (a4), Florence Jaffrezic (a2), Céline Faure (a5), Sébastien Czernichow (a6) (a7), Nathalie di Clemente (a8) (a9), Chrystele Racine (a8) (a9) (a10), Pascale Chavatte-Palmer (a11), Rachel Lévy (a1) and Alifert group...

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