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Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats

  • B. W. Lembede (a1), K. H. Erlwanger (a1), P. Nkomozepi (a2) and E. Chivandi (a1)

Abstract

S-allyl cysteine (SAC) has antioxidant, antidiabetic and antiobesity properties. We hypothesized that neonatal oral administration of SAC would protect rats against neonatal and adulthood high-fructose diet-induced adverse metabolic outcomes in adulthood. In total, 112 (males=56; females=56), 4-day-old Wistar rat pups were randomly allocated to groups and administered the following treatment regimens daily for 15 days from postnatal day (PND) 6–20: group I – 10 ml/kg distilled water, group II – 10 ml/kg 20% fructose solution (FS), group III – 150 mg/kg SAC and group IV – SAC+FS. On PND 21, the pups were weaned and allowed to grow on a standard rat chow (SRC) until PND 56. The rats from each treatment regimen were then randomly split into two subgroups: one on a SRC and plain drinking water and another on SRC and 20% FS as drinking fluid and then subjected to these treatment regimens for 8 weeks after which they were euthanized and tissues collected for analyzes. Neonatal oral administration of SAC attenuated the neonatal high-fructose diet-induced programming for hepatic lipid accretion in adulthood but not against adulthood high-fructose diet-induced visceral obesity. Neonatal oral administration of SAC programmes for protection against neonatal fructose-induced programming for hepatic lipid accumulation thus could potentially protect against fat-mediated liver derangements in adult life.

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Corresponding author

*Address for correspondence: B. W. Lembede, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Republic of South Africa. (Email Busisani.Lembede@wits.ac.za)

References

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Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats

  • B. W. Lembede (a1), K. H. Erlwanger (a1), P. Nkomozepi (a2) and E. Chivandi (a1)

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