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Effect of early postnatal nutrition on chronic kidney disease and arterial hypertension in adulthood: a narrative review

Part of: French DOHaD

Published online by Cambridge University Press:  06 August 2018

C. Juvet ,
U. Simeoni ,
C. Yzydorczyk ,
B. Siddeek ,
J.-B. Armengaud ,
K. Nardou ,
P. Juvet ,
M. Benahmed ,
F. Cachat  and
H. Chehade
C. Juvet*
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
U. Simeoni
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
C. Yzydorczyk
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
B. Siddeek
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
J.-B. Armengaud
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
K. Nardou
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
P. Juvet
Affiliation:
Division of Pediatrics, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
M. Benahmed
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
F. Cachat
Affiliation:
Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
H. Chehade
Affiliation:
Division of Pediatrics, DOHaD Laboratory, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Division of Pediatrics, pediatric nephrology unit, woman-mother-child department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
*
Address for correspondence: C. Juvet, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland. E-mail: Christian.Juvet@chuv.ch
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Abstract

Intrauterine growth restriction (IUGR) has been identified as a risk factor for adult chronic kidney disease (CKD), including hypertension (HTN). Accelerated postnatal catch-up growth superimposed to IUGR has been shown to further increase the risk of CKD and HTN. Although the impact of excessive postnatal growth without previous IUGR is less clear, excessive postnatal overfeeding in experimental animals shows a strong impact on the risk of CKD and HTN in adulthood. On the other hand, food restriction in the postnatal period seems to have a protective effect on CKD programming. All these effects are mediated at least partially by the activation of the renin–angiotensin system, leptin and neuropeptide Y (NPY) signaling and profibrotic pathways. Early nutrition, especially in the postnatal period has a significant impact on the risk of CKD and HTN at adulthood and should receive specific attention in the prevention of CKD and HTN.

Keywords

chronic kidney diseaseDevelopmental Origins of Health and Diseasehypertensionprogramming
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 6 , December 2018 , pp. 598 - 614
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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Footnotes

†

These authors contributed equally to this work.

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