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DOHaD in low- and middle-income countries: a systematic review exploring gaps in DOHaD population studies

Part of: 2019 DOHaD 11th World Congress

Published online by Cambridge University Press:  21 April 2020

Siobhan Tu’akoi ,
Mark H. Vickers Open the ORCID record for Mark H. Vickers [Opens in a new window]  and
Jacquie L. Bay Open the ORCID record for Jacquie L. Bay [Opens in a new window]
Siobhan Tu’akoi
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand
Mark H. Vickers
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand
Jacquie L. Bay*
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand
*
Address for correspondence: Jacquie L. Bay, Liggins Institute, University of Auckland, Private Bag 92109, Victoria Street West, Auckland1142, New Zealand. Email: j.bay@auckland.ac.nz
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Abstract

Low- and middle-income countries (LMICs) are disproportionately affected by non-communicable diseases (NCDs), accounting for more than 80% of NCD-related deaths globally. Research into early-life influences on these diseases via the developmental origins of health and disease (DOHaD) paradigm has informed health promotion interventions and policies focused on optimising early-life health. However, little is known about where this research occurs and whether it reaches and reflects the countries most affected by NCDs. This review searched for DOHaD studies that investigated relationships between factors during pregnancy and at birth, with later-life NCD incidence, risk and related mortality. The aim of this review was to identify where DOHaD research has been conducted and whether this focus is appropriate and relevant, given the differential burden of NCDs. Embase, MEDLINE and Scopus were searched, and eligibility screening processes identified 136 final articles. This review found that 49.7% of DOHaD research was conducted on populations within Western Europe, 15.9% in East Asia, 12.7% in North America, 8.3% in Latin America and the Caribbean, and fewer in Australasia, South Asia, the Middle East, the Africas, and Central Asia. When categorised by income, this review found that 76.4% of studies were based in high-income countries, 19.1% in upper-middle-income and 4.5% in lower-middle-income countries. No studies were based in low-income countries. There is therefore a marked disconnect between where DOHaD research is undertaken and where the greatest NCD disease burden exists. Increasing DOHaD research capacity in LMICs is crucial to informing local strategies that can contribute to reducing the incidence of NCDs.

Keywords

Low and middle incomedevelopmental originsnon-communicable diseases
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 6 , December 2020 , pp. 557 - 563
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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