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Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese

Part of: DOHaD on International Women's Day 2020

Published online by Cambridge University Press:  18 December 2018

R. Tarevnic ,
F. Ornellas ,
C. A. Mandarim-de-Lacerda Open the ORCID record for C. A. Mandarim-de-Lacerda [Opens in a new window]  and
M. B. Aguila
R. Tarevnic
Affiliation:
Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Brazil
F. Ornellas
Affiliation:
Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Brazil
C. A. Mandarim-de-Lacerda
Affiliation:
Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Brazil
M. B. Aguila*
Affiliation:
Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, The University of the State of Rio de Janeiro, Brazil
*
Address for correspondence: M. B. Aguila, Universidade do Estado do Rio de Janeiro, UERJ, Centro Biomédico, Instituto de Biologia, Laboratório de Morfometria, Metabolismo e Doença Cardiovascular. Av 28 de Setembro 87 fds, Rio de Janeiro, RJ 20551-030, Brazil. E-mail: mbaguila@uerj.br
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Abstract

We aimed to evaluate the impact of maternal exercise training on the offspring metabolism and body size caused by father obesity. C57BL/6 male 4-week-old mice were fed a high-fat diet (HF father) or control diet (C father), while equal age female mice were fed only a C diet and were separated into two groups: trained (T mother) and non-trained (NT mother), and at 12 weeks of age mice were mated. A continuous swimming protocol was applied for 10 weeks (before and during gestation), and offspring were followed since weaning until sacrifice (at 12 weeks of age). HF father, compared to C father, showed obesity, elevated total cholesterol (TC) and triglycerides (TG), and glucose intolerance. Both sexes HF/NT offspring showed hyperglycemia, glucose intolerance and high levels of TC and TG, without obesity. However, HF/T offspring showed data close to C/NT, demonstrating the beneficial effect of maternal exercise in the offspring of obese fathers.

Keywords

epigeneticsfather obesityfetal programming
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 4 , August 2019 , pp. 502 - 506
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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