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Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins

  • Muhammad Zahoor Khan (a1), Di Wang (a1), Lei Liu (a1), Tahir Usman (a2), Hui Wen (a1), Ruiqiang Zhang (a1), Shuli Liu (a1), Liangyu Shi (a1), Siyuan Mi (a1), Wei Xiao (a3) and Ying Yu...

Abstract

Improving the production traits and resistance against mastitis in dairy cattle is a challenge for animal scientists across the globe. The present study was designed to investigate the genetic effects of single nucleotide polymorphisms (SNPs) in Janus kinase 2 (JAK2) and diacylglycerol acyltransferase (DGAT1) genes with production and mastitis-related traits. Four SNPs in JAK2 and one in DGAT1 were analyzed through Chinese Cow's SNPs Chip-I (CCSC-I) and genotyped in a population of 312 Chinese Holsteins. Our findings demonstrated that milk fat percentage, somatic cell count (SCC), somatic cell score (SCS), serum cytokines interleukin 6 (IL-6) and interferon gamma (IFN-γ) showed significant associations (P < 0.05) with at least one or more identified SNPs. Consequently, the analysis based on haplotypes amongst the SNPs in JAK2 revealed noteworthy (P < 0.05) association with SCC and IL-6. Collectively, our results verified the pleiotropic ability of detected SNPs in bovine JAK2 and DGAT1 for milk fat percentage as well as mastitis-related traits. The significant SNPs in both the genes could serve as powerful genetic markers to minimize mastitis risk. In addition, besides SCC and SCS, the IFN-γ and IL-6 could also be used as indicators of improved genetic resistance against mastitis.

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Corresponding author

Author for correspondence: Ying Yu, Email: yuying@cau.edu.cn

References

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Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins

  • Muhammad Zahoor Khan (a1), Di Wang (a1), Lei Liu (a1), Tahir Usman (a2), Hui Wen (a1), Ruiqiang Zhang (a1), Shuli Liu (a1), Liangyu Shi (a1), Siyuan Mi (a1), Wei Xiao (a3) and Ying Yu...

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