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The effect of lα-hydroxycholecalciferol on the concentrations of calcium, magnesium and inorganic phosphate in the plasma of parturient cows

Published online by Cambridge University Press:  01 June 2009

Fernando Wittwer  and
Edwin J. H. Ford
Fernando Wittwer
Affiliation:
Department of Veterinary Clinical Studies, University of Liverpool, Leahurst, Neston, Merseyside, L64 7TE
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Summary

135 Cows which were expected to produce a second or subsequent calf within 4–11 d received an intramuscular injection of 500 μg lα-hydroxycholecalciferol (lα-OHD3). In those animals in which the interval between injection and calving was at least 7 d there was, at 7 d after injection of lα-OHD3, a significant increase (P < 0.001) in the blood plasma concentrations of Ca and Pi and a significant reduction (P < 0.05) in that of Mg, compared with those in control animals. Within 24 h of calving there was a significant increase (P < 0.001) in the concentration of Pi but no change in Ca or Mg compared with pre-injection levels, whilst the control animals showed a significant fall (P < 0.001) in the concentration of Ca and a rise in those of Pi (P < 0.001) and Mg (P < 0.05). There was a significant reduction (P < 0.001) in the number of animals with hypocalcaemia (defined as a plasma Ca concentration <1.9 mmol/1) in all animals injected with lα-OHD3; this reduction was particularly marked when the interval between injection and calving was between 1 and 8 d. The previously reported reduction in the incidence of clinical milk fever is considered to be a consequence of the effect of lα-OHD3 on the concentration of Ca in plasma.

Type
Original Articles
Information
Journal of Dairy Research , Volume 47 , Issue 2 , June 1980 , pp. 177 - 183
Copyright
Copyright © Proprietors of Journal of Dairy Research 1980

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References

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